{"id":4754,"date":"2025-09-09T15:24:44","date_gmt":"2025-09-09T13:24:44","guid":{"rendered":"https:\/\/www.pezz.ch\/?page_id=4754"},"modified":"2026-04-21T12:42:25","modified_gmt":"2026-04-21T10:42:25","slug":"syndrome","status":"publish","type":"page","link":"https:\/\/www.pezz.ch\/en\/fuer-familien\/syndrome\/","title":{"rendered":"Syndromes"},"content":{"rendered":"<div class=\"brz brz-root__container brz-reset-all brz-root__container-page\">\n<section id=\"wachstum-kopfbild\" data-brz-id=\"b3fnQC14Esqn_b3fnQC14Esqn\" class=\"brz-section brz-css-d-section brz-css-1pibej2\">\n<div class=\"brz-section__content brz-section--fullWidth brz-css-d-sectionitem-bg brz-css-q10vwo\" data-brz-custom-id=\"qoG5ae_wAadX\">\n<div class=\"brz-bg\">\n<div class=\"brz-bg-image\"><\/div>\n<div class=\"brz-bg-shape brz-bg-shape__bottom\"><\/div>\n<\/div>\n<div class=\"brz-container brz-css-d-sectionitem-container brz-css-lxt1sf\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-r-wrapper brz-css-5kgyep brz-wrapper\">\n<div class=\"brz-spacer brz-css-d-spacer brz-css-1bhssf1\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"syndrome\" data-brz-id=\"maJrR08rmmPm_maJrR08rmmPm\" class=\"brz-section brz-css-d-section brz-css-1eed9sm\">\n<div class=\"brz-section__content brz-section--boxed brz-css-d-sectionitem-bg brz-css-1etitc0\" data-brz-custom-id=\"lKyW62t5peXD\">\n<div class=\"brz-bg\">\n<div class=\"brz-bg-color\"><\/div>\n<\/div>\n<div class=\"brz-container brz-css-d-sectionitem-container brz-css-y9qbpg\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-zv3ezu brz-wrapper\">\n<div class=\"brz-wp__breadcrumbs brz-css-d-wpbreadcrumbs brz-css-v1gal3\" data-brz-custom-id=\"iutYG5RKXixD\">\n<div style=\"min-height:20px\"><\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-mne329 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-uhaa7s\" data-brz-custom-id=\"cWErFpXtvq9C\">\n<div data-brz-translate-text=\"1\">\n<h1 class=\"brz-tp-lg-heading1 brz-css-y0XUg\" data-uniq-id=\"posfN\" data-generated-css=\"brz-css-w8xsF\"><span class=\"brz-cp-color8\">SYNDROMES<\/span><\/h1>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-row__container brz-css-d-row-row brz-css-nd7axh\" data-brz-custom-id=\"jbleIjB1CETP\">\n<div class=\"brz-row brz-css-d-row-container brz-css-r-row-container brz-css-zy8pr6\">\n<div class=\"brz-columns brz-css-d-column-column brz-css-1kin042\" data-brz-custom-id=\"htTa2EJZ1aLx\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-15bav41\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-xzwwqt brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-a4roqd\" data-brz-custom-id=\"tXh7EMaC5TrE\">\n<div data-brz-translate-text=\"1\">\n<h3 class=\"brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_4 brz-ls-lg-0 brz-fw-lg-500 brz-fss-lg-px brz-fs-lg-28 brz-ft-upload brz-ff-hUOhIoGTmLLs brz-tp-lg-heading3 brz-css-hcOyc\" data-generated-css=\"brz-css-fKq6K\" data-uniq-id=\"la7AQ\"><span class=\"brz-underline-true brz-cp-color8\">SYNDROMES WITH HORMONAL DISORDERS<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-columns brz-css-d-column-column brz-css-1umpyz2\" data-brz-custom-id=\"ysQ4jv8v9ctD\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-1jc0cj3\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1p2f5f9 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1cb7v0g\" data-brz-custom-id=\"qC5JTReSlCqA\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-rgOsP\" data-generated-css=\"brz-css-tqT1N\" data-uniq-id=\"n9B92\"><span class=\"brz-cp-color8\">There are hundreds of different syndromes.<\/span><\/p>\n<p class=\"brz-tp-lg-paragraph brz-css-ntxIm\" data-generated-css=\"brz-css-kOPFA\" data-uniq-id=\"xzy3O\"><span class=\"brz-cp-color8\"> <\/span><\/p>\n<p class=\"brz-tp-lg-paragraph brz-css-i_sBv\" data-generated-css=\"brz-css-ga2B6\" data-uniq-id=\"a8RI6\"><span class=\"brz-cp-color8\">Here, we focus on common syndromes associated with hormonal disorders.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"hUKoWN3LecCd_hUKoWN3LecCd\" class=\"brz-section brz-css-d-section brz-css-1yxjkhw\">\n<div class=\"brz-section__content brz-section--fullWidth brz-css-d-sectionitem-bg brz-css-1bdgnjp\" data-brz-custom-id=\"ygh0oqcbo5Zx\">\n<div class=\"brz-bg\">\n<div class=\"brz-bg-color\"><\/div>\n<\/div>\n<div class=\"brz-container brz-css-d-sectionitem-container brz-css-yenjl7\">\n<div class=\"brz-row__container brz-css-d-row-row brz-css-1qe0e7s\" data-brz-custom-id=\"mp6TLvguFRdw\">\n<div class=\"brz-row brz-css-d-row-container brz-css-r-row-container brz-css-nkpywq\">\n<div class=\"brz-columns brz-css-d-column-column brz-css-1riqbrh\" data-brz-custom-id=\"yWELJLN0bxpt\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-11y3ikx\">\n<div class=\"brz-row__container brz-css-d-row-row brz-css-116vbmf\" data-brz-custom-id=\"chdRZ9g5S6tc\">\n<div class=\"brz-row brz-row--inner brz-css-d-row-container brz-css-r-row-container brz-css-11uw6b1\">\n<div class=\"brz-columns brz-css-d-column-column brz-css-14q32oy\" data-brz-custom-id=\"mVKhGkyJy63n\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-12mccec\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-16qkhod brz-wrapper menu-tab-left\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-jqe769\" data-brz-duration=\"300\" data-brz-custom-id=\"hjUKLzyJ022p\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MENU TAB<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-uh7g6c brz-wrapper\">\n<div class=\"brz-menu__container brz-css-d-menu-menu-container brz-css-u806hr\" data-brz-custom-id=\"uEYnzgGedIDG\">\n<nav data-mods=\"%7B%22desktop%22%3A%22horizontal%22%2C%22tablet%22%3A%22horizontal%22%2C%22mobile%22%3A%22horizontal%22%7D\" class=\"brz-menu brz-menu__preview brz-css-d-menu-menu brz-css-sioj35\">\n<ul class=\"brz-menu__ul\" data-menu-items-active=\"\">\n<li data-menu-item-id=\"9bae4c643233a316ed03c0fcf92fe54c\" class=\"brz-menu__item menu-item menu-item-type-custom menu-item-object-custom\"><a class=\"brz-a\" target=\"\" href=\"\/en\/fuer-familien\/syndrome\/#turner\" title=\"\"><span class=\"brz-span\">Turner syndrome<\/span><\/a><\/li>\n<li data-menu-item-id=\"14f448c5202716ecf92c49eaf8959142\" class=\"brz-menu__item menu-item menu-item-type-custom menu-item-object-custom\"><a class=\"brz-a\" target=\"\" href=\"\/en\/fuer-familien\/syndrome\/#sga-mangelgeburt\" title=\"\"><span class=\"brz-span\">SGA (small for gestational age)<\/span><\/a><\/li>\n<li data-menu-item-id=\"4be9d23fc97d2c90200d24b049c3efff\" class=\"brz-menu__item menu-item menu-item-type-custom menu-item-object-custom\"><a class=\"brz-a\" target=\"\" href=\"\/en\/fuer-familien\/syndrome\/#prader-willi\" title=\"\"><span class=\"brz-span\">Prader-Willi Syndrome<\/span><\/a><\/li>\n<li data-menu-item-id=\"63aebfeedcf24d76b4391004dbf6ddd9\" class=\"brz-menu__item menu-item menu-item-type-custom menu-item-object-custom\"><a class=\"brz-a\" target=\"\" href=\"\/en\/fuer-familien\/syndrome\/#noonan\" title=\"\"><span class=\"brz-span\">Noonan Syndrome<\/span><\/a><\/li>\n<li data-menu-item-id=\"805ff24c7c59046d6af6a06d53b1f9f6\" class=\"brz-menu__item menu-item menu-item-type-custom menu-item-object-custom\"><a class=\"brz-a\" target=\"\" href=\"\/en\/fuer-familien\/syndrome\/#kallmann\" title=\"\"><span class=\"brz-span\">Kallmann Syndrome<\/span><\/a><\/li>\n<li data-menu-item-id=\"a58b0b03a808e94603fd1c64e341deeb\" class=\"brz-menu__item menu-item menu-item-type-custom menu-item-object-custom\"><a class=\"brz-a\" target=\"\" href=\"\/en\/fuer-familien\/syndrome\/#klinefelter\" title=\"\"><span class=\"brz-span\">Klinefelter syndrome<\/span><\/a><\/li>\n<\/ul>\n<\/nav>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-columns brz-css-d-column-column brz-css-5b4ptm\" data-brz-custom-id=\"pCW_Wy_YEorm\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-130jduy\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-r-wrapper brz-css-bok1ws brz-wrapper\">\n<div class=\"brz-spacer brz-css-d-spacer brz-css-y6gcqy\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"turner\" data-brz-id=\"g5Yx_UqHqSOi_g5Yx_UqHqSOi\" class=\"brz-section brz-css-d-section brz-css-9z3edh\">\n<div class=\"brz-section__content brz-section--fullWidth brz-css-d-sectionitem-bg brz-css-jqzpnl\" data-brz-custom-id=\"qdQ_li9mLMdg\">\n<div class=\"brz-container brz-css-d-sectionitem-container brz-css-18dshsk\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1s158f3 brz-wrapper\">\n<div class=\"brz-image brz-css-d-image-q90xgfo593eq-parent brz-css-72g3vb\" data-brz-custom-id=\"q90xGFo593eQ\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/11\/pezz-adoleszentenmedizin-01.webp\" loading=\"lazy\" title=\"Arzt spricht mit der jungen Patientin.\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"turner-syndrom-info\" data-brz-id=\"ptBZHMP893dH_ptBZHMP893dH\" class=\"brz-section brz-css-d-section brz-css-1mbyy8v\">\n<div class=\"brz-section__content brz-section--boxed brz-css-d-sectionitem-bg brz-css-q7exi0\" data-brz-custom-id=\"hdgasdDGFPFc\">\n<div class=\"brz-bg\">\n<div class=\"brz-bg-color\"><\/div>\n<\/div>\n<div class=\"brz-container brz-css-d-sectionitem-container brz-css-17uhcwc\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-147d410 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-jt7vdv\" data-brz-custom-id=\"ctwd2p_GnY9r\">\n<div data-brz-translate-text=\"1\">\n<h2 class=\"brz-text-xs-left brz-ff-qKYqBgi9lfgW brz-ft-upload brz-fs-lg-70 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1 brz-vfw-lg-600 brz-fwdth-lg-100 brz-fsft-lg-0 brz-mb-lg-0 brz-mb-sm-0 brz-mb-xs-0 brz-tp-lg-heading2 brz-text-lg-left brz-css-bDs_S\" data-generated-css=\"brz-css-b9Vib\" data-uniq-id=\"hrMYE\"><span class=\"brz-cp-color8\">TURNER SYNDROME IN GIRLS<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-row__container brz-css-d-row-row brz-css-1qd146w\" data-brz-custom-id=\"kCYmLmVL3EA2\">\n<div class=\"brz-row brz-css-d-row-container brz-css-1spljy3\">\n<div class=\"brz-columns brz-css-d-column-column brz-css-47xa7k\" data-brz-custom-id=\"tthFVqUervjt\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-1xc3rzw\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1nw26dn brz-wrapper book-tab\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-17sshgz\" data-brz-duration=\"300\" data-brz-custom-id=\"vIa_XICSAqWx\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">BUCH TAB<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-19dfmwn brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-sqpjee\" data-brz-custom-id=\"nmeEDOg3PoXL\">\n<div data-brz-translate-text=\"1\">\n<p data-uniq-id=\"zu6B5\" data-generated-css=\"brz-css-qbs5O\" class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-yW7Hj\"><span class=\"brz-cp-color8\">For further information, we also refer to the brochure \u201cTurner Syndrome and Its Facets,\u201d which was developed in collaboration with PEZZ, the Turner Syndrome self-help group Switzerland, and Novo Nordisk Pharma AG Switzerland.<\/span><\/p>\n<p data-uniq-id=\"sxoMY\" data-generated-css=\"brz-css-wgXrM\" class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-uXpru\"><a class=\"link--external brz-cp-color1\" href=\"https:\/\/www.turner-syndrom.ch\" data-brz-link-type=\"external\" target=\"_blank\" rel=\"noreferrer noopener\">www.turner-syndrom.ch <\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-11qx9l2 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1xui47g\" data-brz-custom-id=\"kU3FBMcUbzxf\">\n<div data-brz-translate-text=\"1\">\n<h3 class=\"brz-mt-lg-30 brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_4 brz-ls-lg-0 brz-fw-lg-500 brz-fss-lg-px brz-fs-lg-28 brz-ft-upload brz-ff-hUOhIoGTmLLs brz-tp-sm-heading3 brz-tp-lg-heading3 brz-css-j6E4_\" data-generated-css=\"brz-css-wdYua\" data-uniq-id=\"vCTRN\"><span class=\"brz-underline-true brz-cp-color8\">TURNER SYNDROME AFFECTS APPROXIMATELY 15 GIRLS PER YEAR. WITHOUT TREATMENT, IT LEADS TO SHORT STATURE AND UNDERDEVELOPMENT.<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-4srxjq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-473wzv\" data-brz-custom-id=\"d1cRxVvG7Och\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-r4t6B\" data-generated-css=\"brz-css-xziVM\" data-uniq-id=\"q9CLk\"><span class=\"brz-cp-color8\">Turner syndrome (TS) is considered a relatively common disorder; it affects about 1 in 2,500 newborn girls. In Switzerland, approximately 15 girls per year are born with TS. It occurs when, during an early cell division, one of the two X chromosomes is missing or has been damaged. This can be detected through chromosomal analysis.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-ah2nqp brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1vc7q5m\" data-brz-custom-id=\"h2xjnWcnNtBR\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-is1fU\" data-generated-css=\"brz-css-wRfAV\" data-uniq-id=\"yqwb_\"><span class=\"brz-cp-color8\">MAIN CHARACTERISTICS<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1omev3e brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-hb4nuz\" data-brz-custom-id=\"jf14PKZ65NK9\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-tvY5g\" data-uniq-id=\"s_mqF,z7FTE,qtYpS\" data-generated-css=\"brz-css-h_XWH,brz-css-qqQ_y,brz-css-fnNyj\"><span class=\"brz-cp-color8\">The main features of TS are short stature and a lack of pubertal development. Special growth charts are available for girls with Turner syndrome. Without treatment, they reach an average adult height of about 145 cm.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-lBu1V\" data-uniq-id=\"s_mqF,z7FTE,qtYpS\" data-generated-css=\"brz-css-h_XWH,brz-css-qqQ_y,brz-css-fnNyj\"><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-o7dp2\" data-uniq-id=\"qtYpS\" data-generated-css=\"brz-css-fnNyj\"><span class=\"brz-cp-color8\">In addition to short stature, in most cases the ovaries are either not functioning or only partially functional. Instead of normal ovarian tissue containing cells capable of producing hormones and egg cells, the ovaries are usually small and consist mainly of connective tissue. As a result, pubertal development either does not begin or, after a spontaneous onset, quickly comes to a halt. Women with Turner syndrome are also usually infertile (in about 95\u201398% of cases).<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1mo8qe9 brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-1rtmcue\" data-brz-duration=\"300\" data-brz-custom-id=\"nKvYt_j1unyp\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-a7hg12 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-13cr4i9\" data-brz-custom-id=\"eDdiRmn4ydPQ\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-krk_H\" data-uniq-id=\"ejnSJ\" data-generated-css=\"brz-css-k9ZBR\"><span class=\"brz-cp-color8\">If concerns arise due to growth patterns or a lack of pubertal development, leading to the consideration of Turner syndrome in the differential diagnosis, it is important to look for other characteristic signs. However, these are not always present and are often only partially and very subtly expressed: <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-abyya1 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-aj19do\" data-brz-custom-id=\"r61I_a_NIjVx\">\n<div data-brz-translate-text=\"1\">\n<p data-uniq-id=\"m7vdi\" data-generated-css=\"brz-css-xCl6g\" class=\"brz-tp-lg-paragraph brz-css-kPINf\"><span class=\"brz-cp-color8\">EYES<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-i8du66 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-14w2rye\" data-brz-custom-id=\"ouA6yjSvUHez\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-whghL\" data-generated-css=\"brz-css-gu4yp\" data-uniq-id=\"f8mHj\"><span class=\"brz-cp-color8\">Drooping upper eyelids (ptosis), epicanthal folds (epicanthus), nearsightedness (myopia), strabismus (crossed eyes)<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-cwq4m9 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-fce4n6\" data-brz-custom-id=\"zFoLjIwJs6Ro\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-fcT6X\" data-generated-css=\"brz-css-l1TOo\" data-uniq-id=\"bFGds\"><span class=\"brz-cp-color8\">EARS<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1fhxsm8 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-82kq8f\" data-brz-custom-id=\"gTpuL8Xp1A35\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-rbm1d\" data-generated-css=\"brz-css-pNzf1\" data-uniq-id=\"npMUd\"><span class=\"brz-cp-color8\">Malformation of the ear auricles, middle ear infections (otitis media), hearing loss<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-nh9wop brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1jqjojc\" data-brz-custom-id=\"arHHJvFJgOEF\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-oB0_C\" data-generated-css=\"brz-css-ggBwv\" data-uniq-id=\"dDC0W\"><span class=\"brz-cp-color8\">MOUTH, JAW<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-13a0jry brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-iil0s0\" data-brz-custom-id=\"poRk07B581sj\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-nr45y\" data-generated-css=\"brz-css-u8I56\" data-uniq-id=\"m0AAs\"><span class=\"brz-cp-color8\">hoher Gaumen (Palatum arcuatum), kleiner Unterkiefer (Mikrognathie), Zahnfehlstellung<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-jumg70 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-xc7pwj\" data-brz-custom-id=\"aLFewD0jdJ2E\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-mbfon\" data-generated-css=\"brz-css-rTGAq\" data-uniq-id=\"pqYsF\"><span class=\"brz-cp-color8\">SKIN, SKIN APPENDAGES<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-574rp9 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-wl6jnq\" data-brz-custom-id=\"sg54fYF4H61r\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-lGvGi\" data-generated-css=\"brz-css-gx9nY\" data-uniq-id=\"j78DF\"><span class=\"brz-cp-color8\">Swelling of connective tissue in the hands and feet (lymphedema), increased skin moles (pigmented nevi), excessive body hair growth (hypertrichosis), malformation of fingernails and toenails (nail dysplasia), and loss of pigmentation (vitiligo)<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-197ewsz brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-13t91qs\" data-brz-custom-id=\"caXQf8RSbwl6\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-zyzLa\" data-generated-css=\"brz-css-cVHxH\" data-uniq-id=\"eCNKq\"><span class=\"brz-cp-color8\">NECK<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-8w3fhs brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1ldak43\" data-brz-custom-id=\"tw0N6V5iEfj7\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-m_8Gv\" data-uniq-id=\"nDFeL\" data-generated-css=\"brz-css-kiZbY\"><span class=\"brz-cp-color8\">Short, broad neck, low posterior hairline, upward-directed hairline at the back of the neck, lateral skin folds (pterygium colli)<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1o2j36 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-hznbtl\" data-brz-custom-id=\"dDhtbg0W6Q1V\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-r7ww5\" data-uniq-id=\"sIZQ4\" data-generated-css=\"brz-css-iSO3r\"><span class=\"brz-cp-color8\">CHEST<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-vytxwq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1jycmy\" data-brz-custom-id=\"rjgv_sJ5hLBw\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-cEmNX\" data-generated-css=\"brz-css-g8EG0\" data-uniq-id=\"xdGmC\"><span class=\"brz-cp-color8\">Rectangular chest shape (shield chest), wide-spaced nipples, inward-facing (inverted) nipples<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1r4cdgg brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-8sj873\" data-brz-custom-id=\"i5FS6JIlUeTF\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-fNqVf\" data-uniq-id=\"w1Juf\" data-generated-css=\"brz-css-eW4Zq\"><span class=\"brz-cp-color8\">SKELETON<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1lghc3q brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-17sotpv\" data-brz-custom-id=\"pu0DNp34sA4Y\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-uWhY1\" data-generated-css=\"brz-css-leFoA\" data-uniq-id=\"wVYjs\"><span class=\"brz-cp-color8\">weiter Winkel zwischen Ober-und Unterarm (Cubitus valgus), kurze Mittelhandknochen (Brachymetacarpie), Wirbels\u00e4ulenverkr\u00fcmmung (Scoliosis)<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-columns brz-css-d-column-column brz-css-exkyh\" data-brz-custom-id=\"mXiLoYaUsJeH\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-is2kn9\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1ohfbtc brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-199j02y\" data-brz-custom-id=\"yQLoRO_0ljjB\">\n<div data-brz-translate-text=\"1\">\n<h3 class=\"brz-mt-lg-30 brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_4 brz-ls-lg-0 brz-fw-lg-500 brz-fss-lg-px brz-fs-lg-28 brz-ft-upload brz-ff-hUOhIoGTmLLs brz-tp-sm-heading3 brz-tp-lg-heading3 brz-css-lhvNU\" data-generated-css=\"brz-css-sna_M\" data-uniq-id=\"vD0jE\"><span class=\"brz-underline-true brz-cp-color8\">THE FINDINGS ARE IN MOST CASES SO SUBTLE THAT THEY ARE ONLY RECOGNIZED BY AN EXPERIENCED SPECIALIST.<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-4ollxx brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1ddef67\" data-brz-custom-id=\"hYCe4UvpxW0X\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-wZsGH\" data-uniq-id=\"qylw0\" data-generated-css=\"brz-css-d2kXf\"><span class=\"brz-cp-color8\">Most girls and women with Turner syndrome cannot be distinguished from other girls and women.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1xk1vof brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-bd1rj8\" data-brz-custom-id=\"fF5Eh6In6MV1\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-rZQr4\" data-generated-css=\"brz-css-xvVT3\" data-uniq-id=\"jOPTs\"><span class=\"brz-cp-color8\">Various additional disorders occur more frequently in Turner syndrome, although the reason for this remains unknown in most cases. The most common problems that should be actively looked for at the time of diagnosis are kidney and heart malformations, especially abnormalities of the aorta. The following conditions also occur more often than in the general population: thyroid disorders (Hashimoto\u2019s thyroiditis), celiac disease, nearsightedness (myopia), increased intraocular pressure (glaucoma), hearing loss, osteoporosis, and overweight.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1k3vpll brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-10w4ifq\" data-brz-duration=\"300\" data-brz-custom-id=\"o9cbDunkGfK8\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-uw8p35 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1klvyr0\" data-brz-custom-id=\"oixSW6MNjzG6\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-oSe7A\" data-generated-css=\"brz-css-kFLsm\" data-uniq-id=\"j8ho5\"><span class=\"brz-cp-color8\">Girls with Turner syndrome may sometimes experience specific difficulties at school. Typical are specific learning difficulties affecting numerical and mathematical skills as well as spatial orientation.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-yBLdK\" data-generated-css=\"brz-css-otP4B\" data-uniq-id=\"khzbf\"><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-uRAty\" data-generated-css=\"brz-css-kVFVZ\" data-uniq-id=\"bAlGU\"><span class=\"brz-cp-color8\">Es gibt viele Arbeiten \u00fcber psychosoziale Probleme: Die betroffenen M\u00e4dchen sind im Vergleich zu Gesunden \u00e4ngstlicher, weniger aggressiv, emotional unreifer, weniger selbstbewusst und dadurch oft weniger gut in der Gruppe Gleichaltriger integriert. Auf der anderen Seite zeigt eine neuere Studie (2004), dass Turner-M\u00e4dchen erstaunlicherweise oft eine bessere und l\u00e4ngere Ausbildung aufweisen als Gleichaltrige (mehr h\u00f6here Schulen, mehr Universit\u00e4tsabschl\u00fcsse). Dies zeigt, dass Schulprobleme, auch wenn sie h\u00e4ufiger sind als bei anderen, dank ad\u00e4quater Betreuung in der Regel in eine gute schulische und berufliche Leistung m\u00fcnden.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-jdPMh\" data-generated-css=\"brz-css-xClo9\" data-uniq-id=\"dLMq_\"><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-qIjqO\" data-generated-css=\"brz-css-kGGSx\" data-uniq-id=\"fKzA6\"><span class=\"brz-cp-color8\">An early diagnosis is crucial, as the timely initiation of appropriate measures can lead to a normal adult life.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-iXnc8\" data-generated-css=\"brz-css-beCva\" data-uniq-id=\"tHfl6\"><span class=\"brz-cp-color8\">For about 15 years, girls with Turner syndrome have been treated with growth hormone. With early initiation of therapy, final heights of around 160 cm are now no longer uncommon.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-g4mq2a brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-uiz2zd\" data-brz-custom-id=\"q3BjvXMtbKGt\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-diRnU\" data-uniq-id=\"ytCQm\" data-generated-css=\"brz-css-rID7j\"><span class=\"brz-cp-color8\">PUBERTY<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-3lg2du brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-spj3np\" data-brz-custom-id=\"vT2NRnMvkij3\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-gdg45\" data-generated-css=\"brz-css-w33QB\" data-uniq-id=\"mvdwc\"><span class=\"brz-cp-color8\">Im Pubert\u00e4tsalter werden die fehlenden Geschlechtshormone (\u00d6strogene und Gestagene) in dem Alter und dem Entwicklungsstand angepassten Dosen ersetzt \u2013 eine normale Pubert\u00e4tsentwicklung ist die Folge. M\u00e4dchen mit Turner-Syndrom haben bis auf die Eierst\u00f6cke normale weibliche Organe. Sie haben also eine normale Scheide und eine normale Geb\u00e4rmutter. Mit einer Hormonersatzbehandlung werden sie normal menstruieren und auch normal sexuell aktiv sein k\u00f6nnen. Wegen der fehlenden Eizellen sind sie in der Regel aber unfruchtbar.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-16pz9wo brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1b94cgx\" data-brz-custom-id=\"eLfvZen0Mc7z\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-f_YHF\" data-uniq-id=\"u5bO9\" data-generated-css=\"brz-css-mz4VV\"><span class=\"brz-cp-color8\">ADULTHOOD<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-14cpe37 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-fpjnt3\" data-brz-custom-id=\"ckT7ZnQ7Ye9m\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-ytWcE\" data-generated-css=\"brz-css-bKoMQ\" data-uniq-id=\"uOXCX\"><span class=\"brz-cp-color8\">Adult women with Turner syndrome should undergo regular medical check-ups, ideally with a physician who is familiar with Turner syndrome and its associated health issues. Particular attention should be paid to the heart, body weight, blood pressure, bone density, estrogen replacement therapy, and screening for other conditions that occur more frequently, such as hypothyroidism (see above).<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-wrapper-clone brz-flex-xs-wrap brz-css-d-cloneable brz-css-1y1ldj9\" data-brz-custom-id=\"hrqkOdYXSHDo\">\n<div class=\"brz-icon__container\" data-brz-custom-id=\"e5ORVdmXAbQ0\"><span class=\"brz-icon brz-span brz-css-d-icon-icon brz-css-18ruv3v\"><\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"sga-mangelgeburt\" data-brz-id=\"y3Aa4p7i4XpN_y3Aa4p7i4XpN\" class=\"brz-section brz-css-d-section brz-css-19gvltv\">\n<div class=\"brz-section__content brz-section--fullWidth brz-css-d-sectionitem-bg brz-css-19ae6al\" data-brz-custom-id=\"nz7F2FXCNVTV\">\n<div class=\"brz-container brz-css-d-sectionitem-container brz-css-cx1r5z\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-175kyn8 brz-wrapper\">\n<div class=\"brz-image brz-css-d-image-lyufx1rfphvp-parent brz-css-1wb4l2w\" data-brz-custom-id=\"lyufX1RfPhvP\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/12\/pezz-sga.webp\" loading=\"lazy\" title=\"Eine Brosch\u00fcre \u00fcber SGA-Mangelgeburt\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"sga-mangelgeburt-info\" data-brz-id=\"mDhi9Lt8jLEu_mDhi9Lt8jLEu\" class=\"brz-section brz-css-d-section brz-css-1ffxel3\">\n<div class=\"brz-section__content brz-section--boxed brz-css-d-sectionitem-bg brz-css-4v7r61\" data-brz-custom-id=\"zjPYVwajjwjm\">\n<div class=\"brz-bg\">\n<div class=\"brz-bg-color\"><\/div>\n<\/div>\n<div class=\"brz-container brz-css-d-sectionitem-container brz-css-1bqg77v\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-7pqe0f brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-9lhcns\" data-brz-custom-id=\"foCv6sV7vd1g\">\n<div data-brz-translate-text=\"1\">\n<h2 class=\"brz-text-xs-left brz-ff-qKYqBgi9lfgW brz-ft-upload brz-fs-lg-70 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1 brz-vfw-lg-600 brz-fwdth-lg-100 brz-fsft-lg-0 brz-mb-sm-0 brz-mb-xs-0 brz-tp-lg-heading2 brz-text-lg-left brz-mb-lg-0 brz-css-thSKl\" data-generated-css=\"brz-css-mkGDj\" data-uniq-id=\"m9UH7\"><span class=\"brz-cp-color8\">SGA &#8211; MANGELGEBURT<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-row__container brz-css-d-row-row brz-css-skg8lg\" data-brz-custom-id=\"d3WAfhsmFEFa\">\n<div class=\"brz-row brz-css-d-row-container brz-css-163thml\">\n<div class=\"brz-columns brz-css-d-column-column brz-css-1u0fjh8\" data-brz-custom-id=\"taNBfTTVkOWz\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-1qr12tz\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1fxajw6 brz-wrapper book-tab\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-1x3tknh\" data-brz-duration=\"300\" data-brz-custom-id=\"hywC55gPcrNQ\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">BUCH TAB<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1e6bf6 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1xztmse\" data-brz-custom-id=\"xyW9iXGN1V2M\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_3 brz-ls-lg-0 brz-fw-lg-500 brz-fss-lg-px brz-fs-lg-17 brz-ft-upload brz-ff-hUOhIoGTmLLs brz-tp-lg-empty brz-css-pQVDE translation-block\" data-generated-css=\"brz-css-iJEEw\" data-uniq-id=\"sRBsV\">Prof. Dr. med. Urs Eiholzer has written two books in which he explains all important aspects of being born small for gestational age in a sensitive, concise, and accessible way. The guidebook \u201cSGA \u2013 Small for Gestational Age\u201d is aimed at parents of SGA children and helps them better understand the diagnosis.<\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-sq5e6\" data-generated-css=\"brz-css-oTuIZ\" data-uniq-id=\"f5wkS\"><\/p>\n<p class=\"brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_3 brz-ls-lg-0 brz-fw-lg-500 brz-fss-lg-px brz-fs-lg-17 brz-ft-upload brz-ff-hUOhIoGTmLLs brz-tp-lg-empty brz-css-hUkqa\" data-generated-css=\"brz-css-lAUIc\" data-uniq-id=\"g8as6\"><span class=\"brz-cp-color8\">Das im Karger-Verlag erschienene Fachbuch <\/span><a class=\"brz-bold-true brz-cp-color1 link--external\" href=\"https:\/\/www.pezz.ch\/en\/das-pezz\/bestellungen\/\" data-brz-link-type=\"external\"><strong>SGA-Mangelgeburt &#8222;Ursachen, Risiken, Therapien und Behandlung&#8220;<\/strong><\/a><span class=\"brz-cp-color1\"> <\/span><span class=\"brz-cp-color8\">ist ein Muss f\u00fcr \u00c4rzte, die an Wachstumsst\u00f6rungen, Adipositas, Diabetes und dem metabolischen Syndrom interessiert sind. <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1ilgac3 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-19eq4fq\" data-brz-custom-id=\"c1HxQzGBapPQ\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-ccvqE\" data-uniq-id=\"vUT4P\" data-generated-css=\"brz-css-cmEFb\"><a class=\"brz-cp-color1 link--upload\" href=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/12\/SGA_Paediatrica_Urs_Zumsteg.pdf\" data-brz-link-type=\"upload\">SGA und Kleinwuchs \u2013 Indikation <\/a><span class=\"brz-cp-color1 link--upload brz-span\">f\u00fcr Wachstumshormon<\/span><span class=\"brz-cp-color8\"> (PDF), Urs Zumsteg<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-o31zhz brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-yrxnvs\" data-brz-custom-id=\"tEVjLhB02vM4\">\n<div data-brz-translate-text=\"1\">\n<h3 class=\"brz-mt-lg-30 brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_4 brz-ls-lg-0 brz-fw-lg-500 brz-fss-lg-px brz-fs-lg-28 brz-ft-upload brz-ff-hUOhIoGTmLLs brz-tp-sm-heading3 brz-tp-lg-heading3 brz-css-kZzu2\" data-generated-css=\"brz-css-d0Od7\" data-uniq-id=\"ppdaN\"><span class=\"brz-underline-true brz-cp-color8\">TOO SMALL AT BIRTH OR TOO LIGHT FOR GESTATIONAL AGE<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1x2tlco brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-3a5msi\" data-brz-custom-id=\"zDj1Buv2dRPR\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-gr7p3\" data-generated-css=\"brz-css-n4myJ\" data-uniq-id=\"dZvdN\"><span class=\"brz-cp-color8\">If a child is born too small or too light for its gestational age (small for gestational age, SGA), this can have lifelong consequences. Early evaluation is worthwhile, as treatment can support normal development.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1dgex3p brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-b34mks\" data-brz-custom-id=\"sKCh_jq0sHwl\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-lNebc\" data-generated-css=\"brz-css-ltoCn\" data-uniq-id=\"xoysT\"><span class=\"brz-cp-color8\">Sie haben ein Kind bekommen, die Freude ist gross. Sie halten es im Arm und haben das Gef\u00fchl, es sei winzig. Selbst wenn es zum Termin auf die Welt gekommen ist, selbst wenn es nicht Ihr erstes Kind ist, sind Sie \u00fcberrascht oder aufs Neue ber\u00fchrt, wie klein so ein Baby bei der Geburt ist. Klein kommen uns alle Neugeborenen vor, aber sie unterscheiden sich durchaus in Gr\u00f6sse und Gewicht. In der Regel wiegt ein Neugeborenes zwischen 2800 und 4200 Gramm und misst zwischen 47 und 55 Zentimeter. Einige Kinder \u2013 etwa 15% aller Neugeborenen \u2013 entsprechen, wenn sie zur Welt kommen, nicht dieser allgemeinen Norm, sie sind gr\u00f6sser oder kleiner.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-14r4mgc brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-ymtzwz\" data-brz-duration=\"300\" data-brz-custom-id=\"kozHUGVoV4fB\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-143ia07 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1ih3g27\" data-brz-custom-id=\"mN5aiwSx8hNg\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-sLwu4\" data-generated-css=\"brz-css-xR6Fr\" data-uniq-id=\"qXhwG\"><span class=\"brz-cp-color8\">The cause of SGA is usually a lack of nutrients to the fetus. This deficiency can result from maternal undernutrition or, particularly in developed countries, from impaired transfer of nutrients from the mother to the child. In most cases, the exact cause cannot be clearly determined.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-i3xL_\" data-generated-css=\"brz-css-gex1X\" data-uniq-id=\"lmQpw\"><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-qKxA0\" data-generated-css=\"brz-css-qZvS2\" data-uniq-id=\"iJGuS\"><span class=\"brz-cp-color8\">Because the age of first-time mothers has increased over the past decades, more SGA children are being born today. Delaying the wish to have children leads, on the one hand, to more multiple pregnancies and fertility treatments, and on the other hand, older women are more likely to experience pregnancy-related complications.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-16o499a brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-3iph8s\" data-brz-custom-id=\"paJK2qB7DMJf\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-ceEq_\" data-generated-css=\"brz-css-aa2Ft\" data-uniq-id=\"izEry\"><span class=\"brz-cp-color8\">FETAL REPROGRAMMING<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-10kw1fm brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-p8shui\" data-brz-custom-id=\"iuWgWOgh51_J\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-jwMR8\" data-uniq-id=\"zqirO\" data-generated-css=\"brz-css-xP1Zr\"><span class=\"brz-cp-color8\">Studien weisen darauf hin, dass der Organismus des Fetus den Stoffwechsel umschaltet \u2013 und zwar f\u00fcr immer, wenn die Zufuhr an N\u00e4hrstoffen w\u00e4hrend der Schwangerschaft mangelhaft ist. Der Fetus entwickelt aufgrund der \u00abHungersnot\u00bb im Mutterleib eine kompensatorische \u00dcberlebensstrategie und konzentriert sich auf Kosten des Wachstums auf die Versorgung von lebenswichtigen Organen. Das Resultat dieser fetalen Programmierung ist das \u00abbesonders sparsame Individuum\u00bb (thrifty phenotype). <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1q5tkfi brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-16wak2n\" data-brz-duration=\"300\" data-brz-custom-id=\"xIjR5DLoUKmo\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1l00zzk brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-s4jykt\" data-brz-custom-id=\"yUxspvUHQcAI\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-y50Hq\" data-uniq-id=\"xx31w\" data-generated-css=\"brz-css-osw7K\"><span class=\"brz-cp-color8\">These so-called \u201cthrifty phenotypes\u201d (or SGA children) tend to have a smaller body size, a lower metabolic rate, less muscle mass, and reduced physical activity. They are therefore optimally adapted to an environment with chronically limited food availability. In times of famine, this metabolic reprogramming ensures survival. However, if the child is exposed to an environment with abundant nutrition after birth, this programming can lead to health problems.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-columns brz-css-d-column-column brz-css-w3p33o\" data-brz-custom-id=\"sw0TaS3PZC1h\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-1ye80c4\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-lpybdb brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-iyjucd\" data-brz-custom-id=\"sNXUqrUxPLut\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-kFssB\" data-uniq-id=\"nbsuw\" data-generated-css=\"brz-css-dk8PY\"><span class=\"brz-cp-color8\">CONSEQUENCES OF FETAL REPROGRAMMING<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1z061uc brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-zxjnt7\" data-brz-custom-id=\"lKPlyISAwzNr\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-s6LNo\" data-generated-css=\"brz-css-nPdMm\" data-uniq-id=\"mw3rv\"><span class=\"brz-cp-color8\">Very subtle abnormalities in glucose metabolism are often already detectable in childhood. In addition, insufficient supply to both mother and child leads to stress and elevated levels of the stress hormone cortisol, which can have long-lasting effects throughout life. As a result, such children are often more sensitive to stress than others.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1jhuiaf brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-1rhxlt4\" data-brz-duration=\"300\" data-brz-custom-id=\"lg1Ti3Err1h5\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-l7js8g brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1hfm9vv\" data-brz-custom-id=\"zjnOcCWIT15O\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-jQv_i\" data-generated-css=\"brz-css-bFCoA\" data-uniq-id=\"uIlPW\"><span class=\"brz-cp-color8\">All of these mechanisms\u2014namely reduced muscle mass, increased fat mass, less physical activity, reduced pancreatic islet cells, and increased adrenal cortex activity\u2014raise the later risk of insulin resistance. As a result, the susceptibility to type 2 diabetes, high blood pressure, heart attack, and stroke increases in adulthood.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-fnYkq\" data-generated-css=\"brz-css-bFCoA\" data-uniq-id=\"uIlPW\"><span class=\"brz-cp-color8\"> <\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-bAVqZ\" data-generated-css=\"brz-css-bFCoA\" data-uniq-id=\"uIlPW\"><span class=\"brz-cp-color8\">The diagnosis of SGA continues to affect children even at school age. The association between low birth weight and later lower cognitive performance, poorer career prospects, reduced social skills, and behavioural problems is well documented.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-6s7m1m brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-429pkt\" data-brz-custom-id=\"vEeHk8Ezxtze\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-cHVhp\" data-generated-css=\"brz-css-kasTc\" data-uniq-id=\"lmP38\"><span class=\"brz-cp-color8\">TREATMENT OF INSUFFICIENT GROWTH<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-15w120n brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-114h181\" data-brz-custom-id=\"zyoKEnh0vWie\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-tajDX\" data-uniq-id=\"rMp3P\" data-generated-css=\"brz-css-nDFL2\"><span class=\"brz-cp-color8\">Im Laufe der Kindheit steht das Wachstumsproblem im Vordergrund, sp\u00e4ter im Erwachsenenalter dann manchmal die Probleme der Insulinresistenz.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-10yefrm brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-1pxq855\" data-brz-duration=\"300\" data-brz-custom-id=\"cWFUxevXtRul\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-qb25mg brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1b3as55\" data-brz-custom-id=\"fL2bKHbsMH0o\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-mXNid\" data-uniq-id=\"hnjeG\" data-generated-css=\"brz-css-oRQMM\"><span class=\"brz-cp-color8\">Die meisten zu klein geborenen Kinder holen in den ersten zwei Lebensjahren ihr Wachstumsr\u00fcckstand auf. Bei rund zehn Prozent der Kinder, die zu klein und untergewichtig zur Welt gekommen sind, bleibt das Aufholwachstum in dieser Zeit aus. In der Schweiz werden Behandlungskosten mit Wachstumshormon dann \u00fcbernommen, wenn folgende Kriterien erf\u00fcllt sind: Gewicht und\/oder Gr\u00f6sse sind bei der Geburt um 2 Standardabweichungen kleiner als bei Normalgeborenen. Bis zum vierten Lebensjahr findet kein Aufholwachstum statt. Die aktuelle Gr\u00f6sse des Kindes liegt mindestens 2.5 Standardabweichungen unter der Gr\u00f6sse von Gleichaltrigen. Die Wachstumsgeschwindigkeit im vergangenen Jahr betr\u00e4gt weniger als 0 SDS. Die Angleichung an die elterliche Zielgr\u00f6sse betr\u00e4gt mindestens -1 SD. Ausserdem m\u00fcssen vor einer Therapie alle anderen Gr\u00fcnde f\u00fcr Kleinwuchs (z.B. ein Wachstumshormonmangel oder eine Hypothyreose) ausgeschlossen werden. Nach einem Jahr muss die Behandlung evaluiert werden. Ziel der Behandlung ist nicht nur die Beeinflussung des L\u00e4ngenwachstums, sondern auch des Muskelaufbaus zuungunsten des K\u00f6rperfettanteils, weil dies das Risiko von Diabetes reduziert.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-n6k8nf brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1px10af\" data-brz-custom-id=\"lJsIc02ej2l8\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-wl6pT\" data-uniq-id=\"mqFbb\" data-generated-css=\"brz-css-jiiJT\"><span class=\"brz-cp-color8\">EARLY DIAGNOSIS AND TREATMENT ARE CRUCIAL<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-lgkydq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1cznzr8\" data-brz-custom-id=\"jga_AB70_cha\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-dTtPL\" data-generated-css=\"brz-css-xmWSe\" data-uniq-id=\"haqv9\"><span class=\"brz-cp-color8\">We believe it is important for paediatricians to pay early attention if an SGA child has not shown catch-up growth by the age of two, so that any other causes of a growth disorder are not overlooked.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-17bungo brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-ccj8iu\" data-brz-duration=\"300\" data-brz-custom-id=\"hxgqKmHvy33X\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1co2ag5 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-ptv95c\" data-brz-custom-id=\"sAUSF2qRMyLy\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-f3MUH\" data-generated-css=\"brz-css-fLH5_\" data-uniq-id=\"yTFb2\"><span class=\"brz-cp-color8\">Early assessment is also important because increased hormone secretion from the adrenal cortex can lead to a slight acceleration of bone maturation. As a result, it is not uncommon for a seven-year-old SGA child to grow somewhat faster and therefore no longer meet the criteria for treatment. However, this mild acceleration of growth unfortunately usually leads to a slight reduction in final height, as puberty and the associated pubertal growth spurt tend to begin earlier, causing growth to stop sooner.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1pzt1r0 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-huo51e\" data-brz-custom-id=\"gwse1qHBKATI\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-zMhmJ\" data-generated-css=\"brz-css-aa0zZ\" data-uniq-id=\"s6Q2d\"><span class=\"brz-cp-color8\">SILVER-RUSSELL SYNDROME<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1gh16oc brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1fwji7g\" data-brz-custom-id=\"fe6H3KXCB5vh\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-tsIpQ\" data-uniq-id=\"y_lKR\" data-generated-css=\"brz-css-snWv3\"><span class=\"brz-cp-color8\">It is now generally assumed that Silver-Russell syndrome represents a variant of SGA in most cases, with asymmetry between the two sides of the body typically observed in addition to short stature and low body weight.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-wrapper-clone brz-flex-xs-wrap brz-css-d-cloneable brz-css-1dk204k\" data-brz-custom-id=\"grCAd5ZSmsZa\">\n<div class=\"brz-icon__container\" data-brz-custom-id=\"a9tGo0udpctp\"><span class=\"brz-icon brz-span brz-css-d-icon-icon brz-css-1gj2o4e\"><\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-row__container brz-css-d-row-row brz-css-xe6vo9\" data-brz-custom-id=\"c0LdEoTfeLGt\">\n<div class=\"brz-row brz-css-d-row-container brz-css-r-row-container brz-css-133p389\">\n<div class=\"brz-columns brz-css-d-column-column brz-css-4b9hjp\" data-brz-custom-id=\"e3o4uYqf2l3Z\">\n<div class=\"brz-bg\"><\/div>\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-1tgtvg7\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1135ssz brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-kqyato\" data-brz-custom-id=\"zz4_zYDPCXxH\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-cC0yO\" data-generated-css=\"brz-css-jElpS\" data-uniq-id=\"ySZ5M\"><span class=\"brz-cp-color8\">DEFINITION SGA<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-k8iilb brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-owbkh1\" data-brz-custom-id=\"pDIiDJ8Fap04\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-mfYt0\" data-generated-css=\"brz-css-lKQCv\" data-uniq-id=\"vXekZ\"><span class=\"brz-cp-color8\">Die Abk\u00fcrzung SGA steht f\u00fcr &#8222;small for gestational age&#8220;. Unter SGA-Kindern versteht man also Kinder, welche bei Geburt f\u00fcr die Schwangerschaftsdauer untergewichtig und\/oder mit einer zu kleinen Geburtsl\u00e4nge zur Welt kommen (&#8222;Mangelgeburt&#8220;). F\u00fcr die Beurteilung, ob ein Geburtsgewicht und\/oder eine Geburtsl\u00e4nge ungen\u00fcgend sind, werden Normtabellen und Normkurven herbeigezogen. Man spricht in der Regel von SGA, wenn die Gr\u00f6sse und\/oder die L\u00e4nge im untersten 5%-Bereich f\u00fcr Kinder der gleichen Schwangerschaftsdauer liegen. Bei einem am errechneten Termin (40. Schwangerschaftswoche) geborenen M\u00e4dchen oder Knaben heisst dies leichter als 2.63 kg beziehungsweise 2.74 kg und kleiner als etwa 47 cm.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"prader-willi\" data-brz-id=\"tNV7yiyxitiS_tNV7yiyxitiS\" class=\"brz-section brz-css-d-section brz-css-l46uf6\">\n<div class=\"brz-section__content brz-section--fullWidth brz-css-d-sectionitem-bg brz-css-g6syk0\" data-brz-custom-id=\"eKQqtNPVbrd2\">\n<div class=\"brz-container brz-css-d-sectionitem-container brz-css-1q8wup9\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1i00dvm brz-wrapper\">\n<div class=\"brz-image brz-css-d-image-c1vcvq4bkz6x-parent brz-css-1a516e0\" data-brz-custom-id=\"c1vCVq4bkZ6X\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/11\/pezz-prader-willi.webp\" loading=\"lazy\" title=\"Ein Baby ohne K\u00f6rperspanne\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"prader-willi-info\" data-brz-id=\"m57sk6VHZwG__m57sk6VHZwG_\" class=\"brz-section brz-css-d-section brz-css-i4j6hn\">\n<div class=\"brz-section__content brz-section--boxed brz-css-d-sectionitem-bg brz-css-bxtc43\" data-brz-custom-id=\"mmB2NnpvvxYx\">\n<div class=\"brz-bg\">\n<div class=\"brz-bg-color\"><\/div>\n<\/div>\n<div class=\"brz-container brz-css-d-sectionitem-container brz-css-11cyozb\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-169v3jj brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1in33az\" data-brz-custom-id=\"ktg4Nqyxoq8d\">\n<div data-brz-translate-text=\"1\">\n<h2 class=\"brz-text-xs-left brz-ff-qKYqBgi9lfgW brz-ft-upload brz-fs-lg-70 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1 brz-vfw-lg-600 brz-fwdth-lg-100 brz-fsft-lg-0 brz-mb-lg-0 brz-mb-sm-0 brz-mb-xs-0 brz-tp-lg-heading2 brz-text-lg-left brz-css-rP2dp\" data-generated-css=\"brz-css-j1Q3k\" data-uniq-id=\"h8jZj\"><span class=\"brz-cp-color8\">PRADER-WILLI SYNDROME<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-row__container brz-css-d-row-row brz-css-xbx2u9\" data-brz-custom-id=\"df0RlPZcq1EV\">\n<div class=\"brz-row brz-css-d-row-container brz-css-cfbbr4\">\n<div class=\"brz-columns brz-css-d-column-column brz-css-oophbc\" data-brz-custom-id=\"eUYgCDlwPoPz\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-emrn9n\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-qre2pl brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-mqlvgy\" data-brz-custom-id=\"dB5X7qPWlgOE\">\n<div data-brz-translate-text=\"1\">\n<h3 class=\"brz-mt-lg-0 brz-tp-lg-heading3 brz-tp-sm-heading3 brz-ff-hUOhIoGTmLLs brz-ft-upload brz-fs-lg-28 brz-fss-lg-px brz-fw-lg-500 brz-ls-lg-0 brz-lh-lg-1_4 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-b01rA\" data-uniq-id=\"igyKC\" data-generated-css=\"brz-css-n9f09\"><span class=\"brz-cp-color8 brz-underline-true\">DAS PWS &#8211; eine seltene, genetische Krankheit.<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1qa4zwg brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-gcjcov\" data-brz-custom-id=\"zAppxPHltqHt\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-nQX_3\" data-uniq-id=\"kdFbe\" data-generated-css=\"brz-css-b__bc\"><span class=\"brz-cp-color8\">DAS PRADER-WILLI-SYNDROM TRITT DURCHSCHNITTLICH BEI 1 VON 16&#8217;000 NEUGEBORENEN AUF.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-jyl570 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-bt9gds\" data-brz-custom-id=\"tnRUeGcp3BAQ\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-pzNtK\" data-uniq-id=\"ue_sk\" data-generated-css=\"brz-css-mSwIf\"><span class=\"brz-cp-color8\">In Switzerland, approximately 3\u20134 children are born with Prader-Willi syndrome each year. Because families of affected patients had few places to turn to for support, Prof. Dr. Urs Eiholzer began, more than 20 years ago, to take a particular interest in this condition. Today, the Paediatric Endocrinology Centre in Zurich is considered one of the leading centres worldwide for patients with Prader-Willi syndrome.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-c_kEP\" data-uniq-id=\"uQ_40\" data-generated-css=\"brz-css-thTbI\"><span class=\"brz-cp-color8\"> <\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-mX3Mm\" data-uniq-id=\"kp5SD\" data-generated-css=\"brz-css-tVvze\"><span class=\"brz-cp-color8\">Das Prader-Willi-Syndrom wurde 1956 von den Z\u00fcrcher \u00c4rzten Andrea Prader, Alexis Labhart und Heinrich Willi beschrieben. Bereits beim S\u00e4ugling f\u00e4llt eine ausgepr\u00e4gte, generelle Muskelhypotonie auf, das sogenannte &#8222;Waschlappen-Ph\u00e4nomen&#8220;. Zwischen dem 2. und 4. Lebensjahr entwickelt das Kind eine starke Esssucht, die zu \u00dcbergewichtigkeit f\u00fchrt.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-tn1xpa brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-dvr1ys\" data-brz-duration=\"300\" data-brz-custom-id=\"wYaKA0sIXjNP\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-19oxa06 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-13kk1li\" data-brz-custom-id=\"aWOeIlqrx3Px\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-qqlN7\" data-generated-css=\"brz-css-cOPMc\" data-uniq-id=\"n66mT\"><span class=\"brz-cp-color8\">Children grow at a slower pace and show below-average development in terms of gross motor skills and intelligence. A characteristic feature is an altered body composition, with increased fat mass and reduced muscle mass. In adulthood, the average height of patients with Prader-Willi syndrome is 146 cm for women and 152 cm for men. Secondary conditions related to the syndrome itself or to obesity are common.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-tVLyi\" data-generated-css=\"brz-css-cOPMc\" data-uniq-id=\"n66mT\"><span class=\"brz-cp-color8\"> <\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-qjHUn\" data-generated-css=\"brz-css-lrtE3\" data-uniq-id=\"e4YEH\"><span class=\"brz-cp-color8\">The genetic defects underlying Prader-Willi syndrome are largely known. According to current understanding, the symptoms are caused by a dysfunction of the diencephalon.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-jsaIG\" data-generated-css=\"brz-css-k1Hh_\" data-uniq-id=\"r2rw2\"><span class=\"brz-cp-color8\">Thanks to the extensive experience in caring for patients and families, as well as the ongoing scientific evaluation of outcomes, new treatment concepts are developed and implemented at the Paediatric Endocrinology Centre in Zurich. These treatment concepts receive international recognition. In many patients, growth and body proportions can thus be normalised.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-xmewo\" data-generated-css=\"brz-css-o6LpL\" data-uniq-id=\"zKwKg\"><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-columns brz-css-d-column-column brz-css-4h3pj8\" data-brz-custom-id=\"jXdcuGQEMV8l\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-8ai2n4\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1rqrd6w brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-114t1o6\" data-brz-custom-id=\"aRZBOcA2UA8w\">\n<div data-brz-translate-text=\"1\">\n<h3 class=\"brz-mt-lg-0 brz-tp-lg-heading3 brz-tp-sm-heading3 brz-ff-hUOhIoGTmLLs brz-ft-upload brz-fs-lg-28 brz-fss-lg-px brz-fw-lg-500 brz-ls-lg-0 brz-lh-lg-1_4 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-zU4bR\" data-uniq-id=\"tZLAY\" data-generated-css=\"brz-css-xJR4M\"><span class=\"brz-cp-color8 brz-underline-true\">PRADER-WILLI SYNDROME AT A GLANCE<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1txynpu brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-ar7mhb\" data-brz-custom-id=\"eS02J4Ye4sM6\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-t7aNc\" data-generated-css=\"brz-css-mK9j7\" data-uniq-id=\"m3Ttf\"><span class=\"brz-cp-color8\">THE SYNDROME WAS DESCRIBED IN 1956 BY THE ZURICH PHYSICIANS ANDREA PRADER, ALEXIS LABHART, AND HEINRICH WILLI.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1x16dce brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1e1t06y\" data-brz-custom-id=\"moL_fPqQS4af\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-hcwHD\" data-generated-css=\"brz-css-pVMl4\" data-uniq-id=\"vdyVq\"><span class=\"brz-cp-color8\">Its main features are:<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-v50wgm brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1ygg4em\" data-brz-custom-id=\"wgJXDxcYJ7sh\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-aNJCT\" data-generated-css=\"brz-css-mf9H4\" data-uniq-id=\"ikmCN\"><span class=\"brz-cp-color8\">MUSCLE WEAKNESS<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-tdk392 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-10x38kq\" data-brz-custom-id=\"zqtWI0z3D8qS\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-wxBDD\" data-generated-css=\"brz-css-dbhOA\" data-uniq-id=\"ubXvy\"><span class=\"brz-cp-color8\">One of the earliest signs of PWS is muscle weakness. Even in the womb, fetuses with PWS move less than healthy ones, and after birth, infants appear floppy. Their arms and legs seem weak, and they move very little on their own. They are very quiet, respond little to their environment, and sleep a lot.\n\nBecause muscle weakness also affects sucking and swallowing ability, infants with PWS often do not initially take in enough food and are underweight. Over time, the children become stronger and more alert, but a mild to more pronounced degree of muscle weakness usually persists.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-18f1tba brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1uzi6mw\" data-brz-custom-id=\"p1_LS2pPDxys\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-xwQzl\" data-uniq-id=\"ufB2G\" data-generated-css=\"brz-css-p5IWR\"><span class=\"brz-cp-color8\">EXCESSIVE HUNGER (HYPERPHAGIA)<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-vevpcn brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-113zmcw\" data-brz-custom-id=\"qpJtYH8A4Ym6\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-yJPQc\" data-uniq-id=\"l85nB\" data-generated-css=\"brz-css-xcdIk\"><span class=\"brz-cp-color8\">After the period of feeding difficulties and low weight, the eating behaviour of children with PWS changes fundamentally between the ages of two and three. Eating becomes increasingly important. Later on, the children develop an almost insatiable appetite that more or less persists throughout their entire lives.\n\nContinuous supervision and restriction of food intake is the most difficult, but also the most important task for parents and other caregivers of children and adults with PWS. Without clear external limits, this excessive appetite leads to significant weight gain and sometimes severe obesity. Because children with PWS are less active and have less spontaneous movement than other children, they also burn fewer calories.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1k8g52a brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-otw00j\" data-brz-custom-id=\"xiQ60Li0FWUv\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-hBTwr\" data-uniq-id=\"h0EnT\" data-generated-css=\"brz-css-pKQ4r\"><span class=\"brz-cp-color8\">SHORT STATURE (GROWTH RETARDATION)<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-8191x5 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-bqm28i\" data-brz-custom-id=\"sjTvdyFZn1tH\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-jeTjx\" data-generated-css=\"brz-css-nNb7s\" data-uniq-id=\"uFhAq\"><span class=\"brz-cp-color8\">Another important feature of PWS is short stature. The delayed growth, which is already noticeable in early childhood, has lasting effects in adulthood: patients with PWS remain short. On average, women reach a height of 146 cm and men 152 cm.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1uvd8p9 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-17i5bdz\" data-brz-custom-id=\"xvMmMCFCbRuk\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-uC7m5\" data-uniq-id=\"x_pOF\" data-generated-css=\"brz-css-aasrx\"><span class=\"brz-cp-color8\">HYPOGONADISM<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-6l04ch brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1sx1bjg\" data-brz-custom-id=\"zlIIpuAJfF6V\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-oHTJL\" data-generated-css=\"brz-css-fIYHd\" data-uniq-id=\"gJx7Z\"><span class=\"brz-cp-color8\">From birth, children with PWS often show underdevelopment of the genital organs. During puberty, physical development is usually delayed and incomplete. Most young men with PWS do not experience a voice change, and most young women with PWS do not have a menstrual cycle. Interest in sexuality and sexual drive are often low. Due to their physical development, individuals with PWS are in most cases infertile.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1u9fto5 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-18rkgb5\" data-brz-custom-id=\"oBSD6sIYg2oC\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-pYWpr\" data-generated-css=\"brz-css-cMt4M\" data-uniq-id=\"dkxKo\"><span class=\"brz-cp-color8\">KOGNITIVE BEEINTR\u00c4CHTIGUNG<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-b7ypp1 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1p0urqv\" data-brz-custom-id=\"gvORqtXLI2bG\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-aopsS\" data-uniq-id=\"l0hj4\" data-generated-css=\"brz-css-gZzDW\"><span class=\"brz-cp-color8\">The psychomotor and intellectual development of children with PWS is generally already delayed in infancy. Speech and gross motor development (sitting, walking) are particularly affected. While some children are able to attend mainstream school, others show a clear developmental delay compared to their peers. Most feel comfortable in smaller, special education\u2013oriented class settings.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-w3qd5o brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-ykdlkr\" data-brz-custom-id=\"gsv7bA7RxRav\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-cek3Q\" data-uniq-id=\"wtlQX\" data-generated-css=\"brz-css-lSZIY\"><span class=\"brz-cp-color8\">VERHALTENSAUFF\u00c4LLIGKEITEN<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-q1004o brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1fhcfc1\" data-brz-custom-id=\"ueMaag82BipK\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-faMUL\" data-generated-css=\"brz-css-avOKx\" data-uniq-id=\"s7gjo\"><span class=\"brz-cp-color8\">Children with PWS are usually affectionate and compliant in early childhood, but at school age they may sometimes become strongly oppositional, react with sudden anger, and slam doors without being able to calm down. Unpredictable changes in their daily routine are particularly difficult for them, as they like to know exactly\u2014and well in advance\u2014what to expect. Temper tantrums, which affect many children with PWS before puberty, become less frequent later on. However, some adolescents with PWS may experience depressive phases, partly because they become more aware of being different.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1ml515e brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-1jmt9u1\" data-brz-duration=\"300\" data-brz-custom-id=\"eLvaxJy0AJb8\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-kn8mv5 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-13iljkv\" data-brz-custom-id=\"pK2GR5FZha6D\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-cPzFa\" data-generated-css=\"brz-css-t_x3q\" data-uniq-id=\"rU1bD\"><span class=\"brz-cp-color8\">Difficult but very important for parents of children with PWS is the understanding that, despite their best intentions, they cannot make their child \u201chealthy.\u201d The challenges faced by a child with PWS are determined from birth. This insight is crucial in order to prevent both overburdening the child and feelings of guilt in the parents. Even with continuous therapy and the best possible care, the limitations imposed by PWS cannot be overcome.\n\nAt the same time, awareness of these limitations must not discourage parents and caregivers of individuals with PWS. Their commitment, together with support from an interdisciplinary team, is essential for the physical and emotional well-being of the patients and is worthwhile in every case, even when the diagnosis is made later rather than immediately.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-row__container brz-css-d-row-row brz-css-6kfcbk\" data-brz-custom-id=\"oSBWdfhdHpyh\">\n<div class=\"brz-row brz-css-d-row-container brz-css-r-row-container brz-css-d9tot3\">\n<div class=\"brz-columns brz-css-d-column-column brz-css-1dw8syf\" data-brz-custom-id=\"l1nbmExbLyRP\">\n<div class=\"brz-bg\"><\/div>\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-8oun9a\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-lj1d brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1raxanz\" data-brz-custom-id=\"d0KrHOJZuEiw\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-laJ03\" data-uniq-id=\"rYj8B\" data-generated-css=\"brz-css-o_2NM\"><span class=\"brz-cp-color8\">VIDEOS ON THE TOPIC<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-row__container brz-css-d-row-row brz-css-1inupu6\" data-brz-custom-id=\"qBOsqZLH5neW\">\n<div class=\"brz-row brz-row--inner brz-css-d-row-container brz-css-r-row-container brz-css-wtxjty\">\n<div class=\"brz-columns brz-css-d-column-column brz-css-cxjs76\" data-brz-custom-id=\"ldgvwVnqbzB6\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-3suet0\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1ds1q00 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1d7dapa\" data-brz-custom-id=\"lqfJOjmOD3eN\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-erIZZ\" data-uniq-id=\"dvWz5\" data-generated-css=\"brz-css-hRaUM\"><span class=\"brz-cp-color8\">Interview with Urs Eiholzer on Prader-Willi syndrome<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-gaz557 brz-wrapper\">\n<div class=\"brz-video brz-youtube-video brz-video-on-controls-hidden brz-css-d-video brz-css-pjz5v6\" data-brz-custom-id=\"jO_4C4Ndp87T\">\n<div class=\"brz-video-content\" data-loop=\"false\" data-muted=\"false\" data-autoplay=\"off\">\n<div class=\"video-wrapper brz-image-fix-16-9\">\n<div class=\"brz-video-data brz-hidden\" data-src=\"https:\/\/www.youtube.com\/embed\/XaV2d10EOnI?autoplay=0&amp;controls=1&amp;start=0&amp;end=0&amp;modestbranding=0&amp;wmode=transparent&amp;enablejsapi=1&amp;loop=0&amp;rel=0&amp;mute=0\" data-population=\"\" data-controls=\"true\" data-branding=\"true\" data-intro=\"true\" data-start=\"0\" data-end=\"0\" data-loop=\"false\" data-autoplay=\"off\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-columns brz-css-d-column-column brz-css-hsw38\" data-brz-custom-id=\"h2mzLw4GPmqr\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-1g8dkej\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-rghv6e brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-h73u2q\" data-brz-custom-id=\"zh7TDrerIczV\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-c9aeI\" data-generated-css=\"brz-css-tzgHi\" data-uniq-id=\"qwekX\"><span class=\"brz-cp-color8\">\u201cUnremarkable yet remarkable: Living with Prader-Willi syndrome\u201d<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1tc2p4g brz-wrapper\">\n<div class=\"brz-video brz-youtube-video brz-video-on-controls-hidden brz-css-d-video brz-css-1djn3pd\" data-brz-custom-id=\"pELOK2FZtx6S\">\n<div class=\"brz-video-content\" data-loop=\"false\" data-muted=\"false\" data-autoplay=\"off\">\n<div class=\"video-wrapper brz-image-fix-16-9\">\n<div class=\"brz-video-data brz-hidden\" data-src=\"https:\/\/www.youtube.com\/embed\/ShnPZEzAjiI?autoplay=0&amp;controls=1&amp;start=0&amp;end=0&amp;modestbranding=0&amp;wmode=transparent&amp;enablejsapi=1&amp;loop=0&amp;rel=0&amp;mute=0\" data-population=\"\" data-controls=\"true\" data-branding=\"true\" data-intro=\"true\" data-start=\"0\" data-end=\"0\" data-loop=\"false\" data-autoplay=\"off\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-fczgwa brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1btqhrj\" data-brz-custom-id=\"cbCbGUw0Ue1f\">\n<div data-brz-translate-text=\"1\">\n<h3 data-generated-css=\"brz-css-uO1uG\" data-uniq-id=\"pfxyJ\" class=\"brz-text-xs-left brz-ff-qKYqBgi9lfgW brz-ft-upload brz-fs-lg-70 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1 brz-vfw-lg-600 brz-fwdth-lg-100 brz-fsft-lg-0 brz-mb-lg-0 brz-mb-sm-0 brz-mb-xs-0 brz-text-lg-left brz-tp-lg-heading2 brz-css-pdV8q\"><span class=\"brz-cp-color8\">OUR TREATMENT APPROACH<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-130ip70 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1xxx9qj\" data-brz-custom-id=\"zp_qUs15gGJ6\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-yMyOG\" data-generated-css=\"brz-css-nNRJp\" data-uniq-id=\"uOwJy\"><span class=\"brz-cp-color8\">The main challenge of PWS lies in the variability of its symptoms. First, it requires someone\u2014for example, the doctors in the maternity clinic or later the responsible paediatrician\u2014who considers the diagnosis and initiates the necessary investigations. To date, no explanation has been found as to why children with PWS show symptoms of varying severity. For everyday life with a child with PWS, this primarily means one thing:<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-row__container brz-css-d-row-row brz-css-4hdm5v\" data-brz-custom-id=\"iv8kJyKIIw7H\">\n<div class=\"brz-row brz-css-d-row-container brz-css-pp64j2\">\n<div class=\"brz-columns brz-css-d-column-column brz-css-mob1s5\" data-brz-custom-id=\"i_ryyR2TQY5t\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-yfvsi7\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-gj3rur brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1mn4smi\" data-brz-custom-id=\"uE5gkgxouyWT\">\n<div data-brz-translate-text=\"1\">\n<h3 class=\"brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_4 brz-ls-lg-0 brz-fw-lg-500 brz-fss-lg-px brz-fs-lg-28 brz-ft-upload brz-ff-hUOhIoGTmLLs brz-tp-sm-heading3 brz-tp-lg-heading3 brz-mt-lg-0 brz-css-w0v9X\" data-generated-css=\"brz-css-b8FK2\" data-uniq-id=\"aRBvF\"><span class=\"brz-underline-true brz-cp-color8\">JEDES KIND IST ANDERS &#8211; JEDES KIND BRAUCHT ANDERE HILFEN UND INDIVIDUELLE F\u00d6RDERUNG.<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-13yh61e brz-wrapper\">\n<div class=\"brz-image brz-css-d-image-qctfmrggf6j4-parent brz-css-12f48t5\" data-brz-custom-id=\"qcTFMrGGf6j4\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/brizy\/imgs\/theme-pws-06-263x145x0x0x263x145x1769510280.webp\" loading=\"lazy\" title=\"Beschr\u00e4nkung der Kalorienzufuhr\"><\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1oarlpt brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1eeble2\" data-brz-custom-id=\"i5U1ogqZFo6P\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-t6ekL\" data-uniq-id=\"r8WJk\" data-generated-css=\"brz-css-hQUkv\"><span class=\"brz-cp-color8\">CALORIC RESTRICTION<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-183v6z brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-gtzau3\" data-brz-custom-id=\"dtLtaGBchOgs\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-k99gQ\" data-generated-css=\"brz-css-bAlO_\" data-uniq-id=\"mQS2l\"><span class=\"brz-cp-color8\">Erste und wichtigste therapeutische Massnahme ist die Beschr\u00e4nkung der Kalorienzufuhr. Das ist ein permanenter Kampf, der in der Regel nur einigermassen zum Erfolg f\u00fchrt, wenn der K\u00fchlschrank abgeschlossen wird und kein Essen zug\u00e4nglich ist.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1jrh8zh brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-p6eyns\" data-brz-duration=\"300\" data-brz-custom-id=\"aQ9vWgNMt691\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-t1nw2 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1cpa4i3\" data-brz-custom-id=\"c2JmdyUWx_Mh\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-gx3VZ\" data-uniq-id=\"reyvH\" data-generated-css=\"brz-css-bODp7\"><span class=\"brz-cp-color8\">Even strict supervision and consistently locking away food can only limit, but not prevent, overweight or obesity. This is because individuals with PWS have an almost insatiable appetite. The graph shows that children with PWS, unlike other children with similarly high body weight, cannot stop eating when they are allowed to eat as many sandwich portions as they like (PWS children on the right).\nY-axis: number of sandwich portions eaten (1\/4 sandwich).\nX-axis: time<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-drhhkh brz-wrapper\">\n<div class=\"brz-image brz-image__lightbox brz-css-d-image-wkciqmk966xc-parent brz-css-a8gj2y\" data-brz-custom-id=\"wkcIqMk966xC\"><a class=\"brz-a\" target=\"_self\" rel=\"noopener\" href=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/12\/fuenf-finger-modell-1a-sandwiches.webp\" data-brz-link-type=\"lightBox\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/12\/fuenf-finger-modell-1a-sandwiches.webp\" loading=\"lazy\" title=\"Prader-Willi Syndrom: Beschr\u00e4nkung der Kalorienzufuhr\"><\/a><\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-scp37h brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1ni2tm1\" data-brz-custom-id=\"i9P_27k7Wtj0\">\n<div data-brz-translate-text=\"1\">\n<p data-uniq-id=\"sY1Sb\" data-generated-css=\"brz-css-ovFus\" class=\"brz-tp-lg-paragraph brz-css-mWmAK\"><span class=\"brz-cp-color8\">External control is highly effective.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-w9Atx\" data-uniq-id=\"dsQMp\" data-generated-css=\"brz-css-gLX8b\"><span class=\"brz-cp-color8\">This can be parents, family members, or caregivers.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-l4bqf\" data-uniq-id=\"glut8\" data-generated-css=\"brz-css-wsncA\"><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-uCA44\" data-uniq-id=\"wfwQq\" data-generated-css=\"brz-css-pfnci\"><span class=\"brz-cp-color8\">Julia, before and after food control. Notable: just three months and one phone call later. The food control was implemented without us having met the family in person.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1r3x7e0 brz-wrapper\">\n<div class=\"brz-image brz-css-d-image-epzwfixicyfd-parent brz-css-1kbirhe\" data-brz-custom-id=\"ePZwFixICyFD\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/brizy\/imgs\/fuenf-finger-modell-1c-julia-555x396x0x0x555x396x1769510287.webp\" loading=\"lazy\" title=\"Prader-Willi Syndrome\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1eu9cwq brz-wrapper\">\n<div class=\"brz-image brz-css-d-image-i8upfd5fespy-parent brz-css-5k7e60\" data-brz-custom-id=\"i8UpfD5fESPY\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/brizy\/imgs\/theme-pws-07-263x145x0x0x263x145x1769510288.webp\" loading=\"lazy\" title=\"Behandlung mit Wachstumshormon\"><\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1oyb4s9 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-lukc20\" data-brz-custom-id=\"eUvQVCcrRtlU\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-dWrkB\" data-generated-css=\"brz-css-iBMiB\" data-uniq-id=\"gerqs\"><span class=\"brz-cp-color8\">TREATMENT WITH GROWTH HORMONE<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1vecd2t brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-8yzsps\" data-brz-custom-id=\"oEctmnT39cjD\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-fpiNN\" data-generated-css=\"brz-css-pIqis\" data-uniq-id=\"z5J_c\"><span class=\"brz-cp-color8\">Kinder und Erwachsene mit PWS sind kleinw\u00fcchsig. Ende der 1980er Jahre wurde zudem entdeckt, dass sie \u2013 im Vergleich zu gesunden \u00fcbergewichtigen Kindern \u2013 eine verminderte Muskelmasse haben.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1mmdr7h brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-fl70bx\" data-brz-duration=\"300\" data-brz-custom-id=\"kkB9vUBOQN62\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-mwngy3 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-gllt63\" data-brz-custom-id=\"d8SWnLH3a8rq\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-rOBGV\" data-uniq-id=\"zeCiw\" data-generated-css=\"brz-css-k8T8t\"><span class=\"brz-cp-color8\">Short stature and reduced muscle mass are typical symptoms of growth hormone deficiency. For this reason, treatment of children with PWS using growth hormone began in 1990. Several studies have shown that growth, body composition, and physical performance can be significantly improved with growth hormone therapy. Even better results are achieved when treatment is started before the age of 2.5 years.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-12fb2jz brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-d7uq6e\" data-brz-custom-id=\"cEfz6G50IDEj\">\n<div data-brz-translate-text=\"1\">\n<p data-uniq-id=\"c809i\" data-generated-css=\"brz-css-siGqe\" class=\"brz-tp-lg-paragraph brz-css-iHTwI\"><span class=\"brz-cp-color8\">Der gleiche Patient &#8211; zwei Jahre sp\u00e4ter<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-vze_4\" data-uniq-id=\"y64k4\" data-generated-css=\"brz-css-gtBMt\"><span class=\"brz-cp-color8\">Under restricted caloric intake and growth hormone treatment.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-h5g7nw brz-wrapper\">\n<div class=\"brz-image brz-css-d-image-wfqck4ryt4r6-parent brz-css-1njtp6h\" data-brz-custom-id=\"wfQcK4rYt4r6\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/brizy\/imgs\/fuenf-finger-modell-2a-b-555x366x0x0x555x366x1769510286.webp\" loading=\"lazy\" title=\"Prader-Willi Syndrome\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-17ywhki brz-wrapper\">\n<div class=\"brz-image brz-css-d-image-kup8rloklvg5-parent brz-css-w2nycr\" data-brz-custom-id=\"kuP8RlokLvG5\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/brizy\/imgs\/theme-pws-08-263x145x0x0x263x145x1769510284.webp\" loading=\"lazy\" title=\"T\u00e4gliches Training\"><\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-7tu7e4 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-6h56jg\" data-brz-custom-id=\"fJBctTcCZ73g\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-iSkc3\" data-generated-css=\"brz-css-wxyB8\" data-uniq-id=\"i7037\"><span class=\"brz-cp-color8\">DAILY TRAINING<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-s3kclv brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-yediw7\" data-brz-custom-id=\"kB7C_mH5sonw\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-bbOu0\" data-uniq-id=\"kPOaL\" data-generated-css=\"brz-css-pE4NO\"><span class=\"brz-cp-color8\">Inaktivit\u00e4t und wenig Freude an k\u00f6rperlicher Bet\u00e4tigung sind weitere charakteristische Symptome des PWS. Eine Hormontherapie kann zwar das Wachstum normalisieren und die K\u00f6rperzusammensetzung verbessern, aber auch unter langdauernder Wachstumshormonbehandlung bleibt bei PWS-Kindern die Muskelmasse deutlich vermindert und die Fettmasse erh\u00f6ht &#8211; selbst wenn das Gewicht normal ist.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-mIyLZ\" data-uniq-id=\"z9Qcm\" data-generated-css=\"brz-css-kIeTT\"><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1a4cyj1 brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-nlb0yj\" data-brz-duration=\"300\" data-brz-custom-id=\"rFcio4kBdSdP\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-14c25yy brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-zqucxt\" data-brz-custom-id=\"oHUvlaPJUuny\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-gTXg6\" data-uniq-id=\"b6cHa\" data-generated-css=\"brz-css-eBQL0\"><span class=\"brz-cp-color8\">To improve muscle mass and increase energy expenditure, it is beneficial for affected children and adults to follow a structured training programme on a daily basis. The importance of physical activity must be clearly communicated to parents, caregivers, and individuals with PWS. One study showed that 3\u20134 minutes of calf muscle training per day (3 sets of 12 repetitions) led to an increase in calf circumference in both children with PWS and their healthy siblings. The low muscle mass in children with PWS is largely a consequence of inactivity. The same applies to muscle strength.\n\nAnd the surprising finding: after training, children with PWS spontaneously walk significantly longer distances, meaning that enjoyment of movement can be activated. Before training, the spontaneous walking distance was 10 km over 3 days; after training, it increased to 18 km. (No significant change was observed in healthy children.)<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-17dgjb5 brz-wrapper\">\n<div class=\"brz-image brz-css-d-image-xbup3qajjhdw-parent brz-css-1n6w9wy\" data-brz-custom-id=\"xbup3qAjjhdW\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/brizy\/imgs\/fuenf-finger-modell-3a-555x765x0x0x555x765x1769510282.webp\" loading=\"lazy\" title=\"Prader-Willi Syndrome\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-c868n8 brz-wrapper\">\n<div class=\"brz-image brz-css-d-image-fx8s_lvzbjmp-parent brz-css-qywmvc\" data-brz-custom-id=\"fx8S_LVZBJMp\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/brizy\/imgs\/theme-pws-09-263x145x0x0x263x145x1769510288.webp\" loading=\"lazy\" title=\"Substitution mit Geschlechtshormonen\"><\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-x1p40s brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-3m23ur\" data-brz-custom-id=\"jun8fiHK33ki\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-vUpxu\" data-uniq-id=\"aObtm\" data-generated-css=\"brz-css-so8NA\"><span class=\"brz-cp-color8\">SUBSTITUTION WITH SEX HORMONES<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-19wkg3o brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1u8ly44\" data-brz-custom-id=\"eNp2AH0EZZuu\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-nIDsc\" data-generated-css=\"brz-css-jQijj\" data-uniq-id=\"lGuHX\"><span class=\"brz-cp-color8\">The stagnation of pubertal development is very distressing for those affected\u2014for example, the absence of voice breaking in male adolescents. The underlying cause is a central feature of PWS and is called \u201chypogonadism.\u201d This so-called underfunction of the testes or ovaries not only affects pubertal development and psychological maturation, but also growth and body composition.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-9zhije brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-g8a8j0\" data-brz-duration=\"300\" data-brz-custom-id=\"aZvWFFejyifq\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-19of1yh brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1s1gin1\" data-brz-custom-id=\"mrexb_ZKvDD1\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-xorSj\" data-uniq-id=\"pgpKc\" data-generated-css=\"brz-css-itKy4\"><span class=\"brz-cp-color8\">Prader\u2013Willi syndrome and Hypogonadism &#8211; IPWSO<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1wz8sx2 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1ipsonu\" data-brz-custom-id=\"edzHLJDqNIOL\">\n<div data-brz-translate-text=\"1\">\n<p data-generated-css=\"brz-css-ydiyz\" data-uniq-id=\"dr5hT\" class=\"brz-tp-lg-paragraph brz-css-konLx\"><span class=\"brz-cp-color8\">Puberty<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-ytecp7 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-n29s3d\" data-brz-custom-id=\"bAo0kHFeat6L\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-nxC_7\" data-generated-css=\"brz-css-tWdHs\" data-uniq-id=\"cvEVk\"><span class=\"brz-cp-color8\">Dass die Pubert\u00e4t oft unvollst\u00e4ndig bleibt liegt an einer Fehlregulierung des Zwischenhirns von PWS-Betroffenen. Bedingt durch die unterschiedliche Produktion der Geschlechtshormone ist dies bei Jungen und M\u00e4dchen verschieden: <\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-aBo5d\" data-generated-css=\"brz-css-tWdHs\" data-uniq-id=\"cvEVk\">\t<span class=\"brz-cp-color8\">&#8211; \u00d6strogene werden nicht nur in den Eierst\u00f6cken, sondern auch im Fettgewebe hergestellt. Deshalb haben M\u00e4dchen weitgehend eine normale Pubert\u00e4t, meist aber ohne Zyklus. <\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-hLrsZ\" data-generated-css=\"brz-css-tWdHs\" data-uniq-id=\"cvEVk\">\t<span class=\"brz-cp-color8\">&#8211; Testosteron wird praktisch nur in den Hoden produziert, deshalb haben PWS-Jungen wenig Pubert\u00e4tsentwicklung, insbesondere ohne Stimmbruch.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-ipTUR\" data-generated-css=\"brz-css-tWdHs\" data-uniq-id=\"cvEVk\"><span class=\"brz-cp-color8\">Und: Jungen brauchen Testosteron f\u00fcr die Muskelbildung.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-uJa_S\" data-generated-css=\"brz-css-zhxbs\" data-uniq-id=\"eAEPw\"><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-rQSEy translation-block\" data-generated-css=\"brz-css-tBTBv\" data-uniq-id=\"kBNa8\">Although hypogonadism in PWS is well documented, the replacement of sex hormones remains partly controversial to this day. This is mainly based on the long-standing belief that an increase in the male sex hormone testosterone could lead to more aggressive behaviour in young men. To date, however, no scientific studies in individuals with PWS have confirmed this.\n\nIn our experience, we have had consistently good results with sex hormone replacement in adolescents with PWS, provided that treatment is started at the physiologically appropriate time.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1ly8w4l brz-wrapper\">\n<div class=\"brz-image brz-image__lightbox brz-css-d-image-zx4psks4_5jh-parent brz-css-1qpiup0\" data-brz-custom-id=\"zX4psKS4_5jh\"><a class=\"brz-a\" target=\"_self\" rel=\"noopener\" href=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/12\/fuenf-finger-modell-4a.webp\" data-brz-link-type=\"lightBox\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/12\/fuenf-finger-modell-4a.webp\" loading=\"lazy\" title=\"Hypogonadismus Prader-Willi Syndrom\"><\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1gs8mk1 brz-wrapper\">\n<div class=\"brz-image brz-css-d-image-sk6hujiaezvy-parent brz-css-1s2ouk1\" data-brz-custom-id=\"sK6HuJIAezVY\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/brizy\/imgs\/theme-pws-10-263x145x0x0x263x145x1769510280.webp\" loading=\"lazy\" title=\"Familiencoaching\"><\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-12h8ghs brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-olno7t\" data-brz-custom-id=\"yiSbKWBdzf7I\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-buKsK\" data-uniq-id=\"aRJnv\" data-generated-css=\"brz-css-vt7Ug\"><span class=\"brz-cp-color8\">FAMILY COACHING<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1sl0ho0 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1kck6ni\" data-brz-custom-id=\"yR1e2qQV9gry\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-xogm8\" data-uniq-id=\"nBnE8\" data-generated-css=\"brz-css-xGD0V\"><span class=\"brz-cp-color8\">Families with children with PWS are usually exposed to greater psychosocial stress than other families.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-oJhHB\" data-uniq-id=\"xWFaN\" data-generated-css=\"brz-css-lYJBg\"><span class=\"brz-cp-color8\">Therefore, we consider supporting the family to be particularly important, for example<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-qlJ79\" data-uniq-id=\"aGulN\" data-generated-css=\"brz-css-hKIar\"><\/p>\n<ul>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-ghdbm\" data-uniq-id=\"jvwou\" data-generated-css=\"brz-css-gvuJ0\"><span class=\"brz-cp-color8\">in restricting caloric intake over 24 hours<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-cd5_i\" data-uniq-id=\"ovYw7\" data-generated-css=\"brz-css-iUTCE\"><span class=\"brz-cp-color8\">in implementing a structured daily exercise programme<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-f2keZ\" data-uniq-id=\"q_uMX\" data-generated-css=\"brz-css-vi4RN\"><span class=\"brz-cp-color8\">in cases of temper outbursts, stubbornness, depression, social withdrawal, and \u201cskin picking\u201d<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-pJOSE\" data-uniq-id=\"fIMXQ\" data-generated-css=\"brz-css-jFb_D\"><span class=\"brz-cp-color8\">in medical interventions and treatments<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-lMC3T\" data-uniq-id=\"eAeLE\" data-generated-css=\"brz-css-tDpXV\"><span class=\"brz-cp-color8\">in educational support services and in finding schools and residential placements<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-xtgui\" data-uniq-id=\"qIUsf\" data-generated-css=\"brz-css-nsw1n\"><span class=\"brz-cp-color8\">bei beh\u00f6rdlichen Angelegenheiten<\/span><\/li>\n<\/ul>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-z6rR6\" data-uniq-id=\"fcVVF\" data-generated-css=\"brz-css-tMlpO\"><span class=\"brz-cp-color8\"> <\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-pztW3\" data-uniq-id=\"s4VRO\" data-generated-css=\"brz-css-pWQL8\"><span class=\"brz-cp-color8\">Families should generally feel secure and well supported. This requires a case manager who can coordinate and integrate the various findings from the different specialists.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-3s3uwp brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-1dl5vxg\" data-brz-duration=\"300\" data-brz-custom-id=\"jbf18wohn8Km\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-15mload brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-k32784\" data-brz-custom-id=\"yaKGX355cmFw\">\n<div data-brz-translate-text=\"1\">\n<p data-generated-css=\"brz-css-xjHIb\" data-uniq-id=\"eHw9f\" class=\"brz-tp-lg-paragraph brz-css-cf0up\"><span class=\"brz-cp-color8\">The easy, conflict-free path is not always the best. Thoughts by Urs Eiholzer.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1sr93ea brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1bw8vhu\" data-brz-custom-id=\"eZg7sKv23bYu\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-qZ69F\" data-generated-css=\"brz-css-spEGV\" data-uniq-id=\"xwbse\"><span class=\"brz-cp-color8\">In the past, Prader-Willi syndrome was primarily associated with hyperphagia and intellectual disability. From the 1990s onwards, attention shifted to hypothalamic dysfunction, with a focus mainly on endocrine management. However, for about 40 years it has been known that, in PWS, psychiatric conditions are central in the medium and long term and are decisive for the quality of life of affected individuals and their families\u2014and this remains true today.\n\nAgainst the background of sometimes severe psychiatric disorders, somatic care is in fact secondary and, in comparison, relatively straightforward.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-fi0yI\" data-generated-css=\"brz-css-fgPdU\" data-uniq-id=\"ulbE5\"><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-he4vL\" data-generated-css=\"brz-css-ppAjv\" data-uniq-id=\"vPavJ\"><span class=\"brz-cp-color8\">Professor Prader hat mich damals mit der Betreuung seiner Patienten mit Prader Willi Syndrom beauftragt, weil ich einerseits bei ihm zum Facharzt f\u00fcr Endokrinologie ausgebildet wurde und andererseits, weil er meine langj\u00e4hrige Ausbildung und T\u00e4tigkeit als Psychotherapeut mit psychoanalytischem und familientherapeutischem Hintergrund kannte und sch\u00e4tzte. Damals war noch nicht bekannt, dass PWS Betroffene in der sp\u00e4ten Kindheit und im Erwachsenenleben derart h\u00e4ufig an schwersten psychischen St\u00f6rungen erkrankten. Es ging Prader darum, die depressive Grundstimmung der Eltern und des Familiensystems aufzufangen, welche weitgehend aus der Ohnmacht der Medizin entstand und als Folge die Eltern und Angeh\u00f6rigen hilflos liess. Um aus dieser Hilflosigkeit auszubrechen, habe ich damals zusammen mit der Elterngruppe, deren Gr\u00fcndungsmitglieder Andrea Prader und ich waren, Studien \u00fcber das PWS begonnen und neue Entdeckungen in Publikationen und B\u00fcchern beschrieben. Die allgemeine depressive Grundstimmung der Familien ist damals dank dieser Erkenntnisse und entsprechend neuen Therapieangeboten von einer neuen Welle des Optimismus in den betroffenen Familien abgel\u00f6st worden. Bald zeigte sich aber die andere Seite. Je normaler unsere Patienten mit Prader Willi Syndrom ausgesehen haben und wahrgenommen wurden, desto auffallender wurden ihre geistigen und psychischen Defizite und desto st\u00e4rker sind die h\u00e4ufigen massiven psychischen St\u00f6rungen wie Depressionen und Psychosen. Ich erinnere mich an eine Fahrt der PWS Eltern an einen Kongress der IPWSO in Jesolo. Auf der Hinfahrt waren alle gl\u00fccklich und auf der Heimfahrt haben viele geweint. An diesem Kongress wurde zum ersten Mal breitfl\u00e4chig dar\u00fcber gesprochen, wie h\u00e4ufig und wie massiv die psychischen Auff\u00e4lligkeiten bei \u00e4lteren Kindern und Erwachsenen sind. L\u00f6sungen waren noch keine in Sicht. Ich habe fr\u00fch bemerkt, dass es f\u00fcr den sp\u00e4teren Verlauf von entscheidender Bedeutung ist, die famili\u00e4re Struktur zu beeinflussen und insbesondere die Eltern dazu zu bringen, die Kinder mit Prader Willi Syndrom in einer klar strukturierten Familiensituation aufwachsen zu lassen \u2013 eine Erkenntnis, die heute insbesondere im englischen Sprachraum v\u00f6llig unwidersprochen ist. Alle Familien, die ich je betreut habe, wurden auch psychotherapeutisch in einem Familiensetting betreut und gecoacht, ohne dass sie das immer wahrgenommen haben. Viele Familien die ich betreut habe, d\u00fcrften sich an harte Auseinandersetzungen mit mir erinnern, weil ich immer versucht habe, die Zukunft der psychischen Gesundheit dieser Kinder im Auge zu behalten. Ich habe oft gesagt, dass die Kindheit nur ein \u00dcbergang ist und dass auch vom Prader Willi Syndrom Betroffene nachher noch 60 Jahre oder l\u00e4nger erwachsen sein k\u00f6nnten und dass die Kindheit dazu dient, dass die Betroffenen das Erwachsenenleben mit einer m\u00f6glichst hohen Lebensqualit\u00e4t meistern k\u00f6nnen. Wahrscheinlich w\u00e4ren auch damals verschiedentlich einige Eltern gerne davongelaufen. Sie konnten allerdings nicht, da es ganz einfach keine weitere Fachstelle f\u00fcr die Betreuung vom Prader-Willi Syndrom Betroffenen in der Schweiz gab.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-tyGV2\" data-generated-css=\"brz-css-h_fd2\" data-uniq-id=\"fySbE\"><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-a7efi\" data-generated-css=\"brz-css-srr3m\" data-uniq-id=\"aLmST\"><span class=\"brz-cp-color8\">If one focuses solely on the biological aspects of individuals with PWS, the approach is of course different and much less conflict-laden. However, it does not correspond to my treatment philosophy or my personal approach that a physician adopts the family\u2019s perspective and only says what they want to hear. This is nothing more than an echo chamber, which exposes the later mental health of older children and adults with PWS to additional risks.\n\nI am convinced that those families who are able to seize the opportunity should be given that chance.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-vi935h brz-wrapper\">\n<div class=\"brz-image brz-css-d-image-vykwebsuzhgo-parent brz-css-1m493xg\" data-brz-custom-id=\"vYKWebsuzhGO\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/brizy\/imgs\/fuenf-finger-modell-surfbrett-555x416x0x0x555x416x1769510280.webp\" loading=\"lazy\" title=\"Prader-Willi Syndrom - Kinder auf dem Surfbrett\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-columns brz-css-d-column-column brz-css-1a6aac\" data-brz-custom-id=\"hgU2DMqngVUJ\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-1g0u0x8\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-il6q45 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1we0smx\" data-brz-custom-id=\"u9nGxWeWwjSX\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-ykV8z\" data-uniq-id=\"ch8Ea\" data-generated-css=\"brz-css-gak6r\"><span class=\"brz-cp-color8\">EARLY INTERVENTION, PHYSIOTHERAPY, SPEECH THERAPY<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-13gjccc brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-io9nvy\" data-brz-custom-id=\"g_g7xbk1Obae\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-bN9Q_\" data-generated-css=\"brz-css-pBpbk\" data-uniq-id=\"lFXnv\"><span class=\"brz-cp-color8\">Entsprechend den spezifischen Bed\u00fcrfnissen des Kindes und dem lokalen Therapieangebot werden bereits im S\u00e4uglings- und Kleinkindalter die notwendigen F\u00f6rdermassnahmen angeboten.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-bgC1x\" data-generated-css=\"brz-css-gt7zm\" data-uniq-id=\"jw90K\"><\/p>\n<p class=\"brz-tp-lg-empty brz-ff-hUOhIoGTmLLs brz-ft-upload brz-fs-lg-17 brz-fss-lg-px brz-fw-lg-500 brz-ls-lg-0 brz-lh-lg-1_3 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-nzVzv\" data-generated-css=\"brz-css-t3XGH\" data-uniq-id=\"dtVXN\"><strong class=\"brz-cp-color8 brz-bold-true\">MUSCLE STRENGTHENING<\/strong><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-qK7R5\" data-generated-css=\"brz-css-rHDOV\" data-uniq-id=\"ykZol\"><span class=\"brz-cp-color8\">Physiotherapy should primarily focus on strengthening the muscles, given the persistent muscle weakness and insufficient muscle mass. Early intervention aims to encourage the child to reach developmental milestones.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-rnBdA\" data-generated-css=\"brz-css-szycI\" data-uniq-id=\"jOvot\"><span class=\"brz-cp-color8\"> <\/span><\/p>\n<p class=\"brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_3 brz-ls-lg-0 brz-fw-lg-500 brz-fss-lg-px brz-fs-lg-17 brz-ft-upload brz-ff-hUOhIoGTmLLs brz-tp-lg-empty brz-css-tpwMg\" data-generated-css=\"brz-css-j_z67\" data-uniq-id=\"jv2k_\"><strong class=\"brz-bold-true brz-cp-color8\">SPEECH THERAPY<\/strong><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-dtFXd\" data-generated-css=\"brz-css-teXfW\" data-uniq-id=\"l7wto\"><span class=\"brz-cp-color8\">In cases of delayed or impaired language development, speech therapy counselling should begin around the child\u2019s third birthday as the most important measure. <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1mlyuej brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1nlrp5j\" data-brz-custom-id=\"yygD8s337nfC\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-nIQEj\" data-uniq-id=\"loszd\" data-generated-css=\"brz-css-s5u52\"><span class=\"brz-cp-color8\">PSYCHOLOGICAL COUNSELLING<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-19iius4 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-mnyyzj\" data-brz-custom-id=\"wp26bv6jD44Z\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-f8_Eb\" data-uniq-id=\"qINz5\" data-generated-css=\"brz-css-khnF6\"><span class=\"brz-cp-color8\">Families with children with PWS are usually exposed to greater psychosocial stress than other families.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-az5Ts\" data-uniq-id=\"rYxUo\" data-generated-css=\"brz-css-rJyzV\"><\/p>\n<p class=\"brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_3 brz-ls-lg-0 brz-fw-lg-500 brz-fss-lg-px brz-fs-lg-17 brz-ft-upload brz-ff-hUOhIoGTmLLs brz-tp-lg-empty brz-css-jpJok\" data-uniq-id=\"toCAj\" data-generated-css=\"brz-css-dkWyS\"><strong class=\"brz-bold-true brz-cp-color8\">Prudent use of resources<\/strong><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-xysP5\" data-uniq-id=\"gwhi2\" data-generated-css=\"brz-css-zJ0Cc\"><span class=\"brz-cp-color8\">Ausserdem hat sich gezeigt, dass die Erziehung von Kindern mit PWS einen bedeutenden Einfluss auf deren Gewichtsentwicklung haben kann. Psychologische Beratung von Eltern oder Familien zielt deshalb einerseits darauf ab, die Betroffenen zu unterst\u00fctzen und ihnen im haush\u00e4lterischen Umgang mit ihren Ressourcen zu helfen, und andererseits auf eine Beeinflussung des Erziehungsverhaltens in Richtung mehr Klarheit und Konsequenz. Die Erfahrung zeigt aber auch, dass es den Familien oft nicht leicht f\u00e4llt, sich einzugestehen, dass die eigenen Ressourcen nicht mehr ausreichen und dass sie Hilfe und Unterst\u00fctzung von aussen brauchen.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-wrapper-clone brz-flex-xs-wrap brz-css-d-cloneable brz-css-10g5z2u\" data-brz-custom-id=\"zcDSUNOGNFiZ\">\n<div class=\"brz-icon__container\" data-brz-custom-id=\"yTYsqywOe3Ph\"><span class=\"brz-icon brz-span brz-css-d-icon-icon brz-css-m65a0r\"><\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"noonan\" data-brz-id=\"gOu8BtNLxLOf_gOu8BtNLxLOf\" class=\"brz-section brz-css-d-section brz-css-zxxrfy\">\n<div class=\"brz-section__content brz-section--fullWidth brz-css-d-sectionitem-bg brz-css-xk6dtx\" data-brz-custom-id=\"f12YCinOPpJt\">\n<div class=\"brz-container brz-css-d-sectionitem-container brz-css-1azh71v\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1wi87hm brz-wrapper\">\n<div class=\"brz-image brz-css-d-image-ez4uugzvazpi-parent brz-css-u3o5t1\" data-brz-custom-id=\"eZ4uuGZvaZpi\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/11\/pezz-noonan-1.webp\" loading=\"lazy\" title=\"Ein Kind mit Noonan-Syndrom bl\u00e4st eine Pusteblume\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"noonan-infos\" data-brz-id=\"lz71QDfP3vRc_lz71QDfP3vRc\" class=\"brz-section brz-css-d-section brz-css-1fnvcxy\">\n<div class=\"brz-section__content brz-section--boxed brz-css-d-sectionitem-bg brz-css-8hwvfz\" data-brz-custom-id=\"a4pDzIESKqsQ\">\n<div class=\"brz-bg\">\n<div class=\"brz-bg-color\"><\/div>\n<\/div>\n<div class=\"brz-container brz-css-d-sectionitem-container brz-css-3rvjsl\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1q0g3dq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-30v9ef\" data-brz-custom-id=\"v5_0hGchHpkF\">\n<div data-brz-translate-text=\"1\">\n<h2 class=\"brz-text-xs-left brz-ff-qKYqBgi9lfgW brz-ft-upload brz-fs-lg-70 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1 brz-vfw-lg-600 brz-fwdth-lg-100 brz-fsft-lg-0 brz-mb-lg-0 brz-mb-sm-0 brz-mb-xs-0 brz-tp-lg-heading2 brz-text-lg-left brz-css-yIcTj\" data-generated-css=\"brz-css-vUi_E\" data-uniq-id=\"ahSQY\"><span class=\"brz-cp-color8\">NOONAN-SYNDROM<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-row__container brz-css-d-row-row brz-css-euwj91\" data-brz-custom-id=\"h1AHlgVHjm7X\">\n<div class=\"brz-row brz-css-d-row-container brz-css-1u604vi\">\n<div class=\"brz-columns brz-css-d-column-column brz-css-1ov7ahn\" data-brz-custom-id=\"s7C2XraF95B7\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-1oti3la\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-jjynub brz-wrapper book-tab\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-kbdh8r\" data-brz-duration=\"300\" data-brz-custom-id=\"h1WXcC9RTQXe\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">BUCH TAB<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-ndpp3h brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-16bz8au\" data-brz-custom-id=\"vJYDamZKuZdJ\">\n<div data-brz-translate-text=\"1\">\n<p data-uniq-id=\"y_ofF\" data-generated-css=\"brz-css-g1eDX\" class=\"brz-ff-hUOhIoGTmLLs brz-ft-upload brz-fs-lg-22 brz-fss-lg-px brz-fw-lg-500 brz-ls-lg-0 brz-lh-lg-1_4 brz-vfw-lg-600 brz-fwdth-lg-100 brz-fsft-lg-0 brz-tp-lg-uSRJcAJTJCVu brz-css-tAnwE\"><span class=\"brz-cp-color8 brz-italic-true\">Read more about Noonan syndrome in our brochure <\/span><a class=\"brz-cp-color8 brz-italic-true link--external\" href=\"https:\/\/www.pezz.ch\/en\/ueber-uns\/buecher\/\" data-brz-link-type=\"external\">&#8222;Das Noonan-Syndrom &#8211; Wie erkennt man es? Wie unterst\u00fctzt man Betroffene&#8220;<\/a><span class=\"brz-cp-color8 brz-italic-true\"> <\/span><\/p>\n<p class=\"brz-tp-lg-empty brz-ff-hUOhIoGTmLLs brz-ft-upload brz-fs-lg-22 brz-fss-lg-px brz-fw-lg-500 brz-ls-lg-0 brz-lh-lg-1_4 brz-vfw-lg-600 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-eDIl6\" data-uniq-id=\"gwm6j\" data-generated-css=\"brz-css-e7fcr\"><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1mht1wy brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-h6d7t\" data-brz-custom-id=\"mAmcSOlVZBa9\">\n<div data-brz-translate-text=\"1\">\n<h3 class=\"brz-tp-lg-heading3 brz-tp-sm-heading3 brz-ff-hUOhIoGTmLLs brz-ft-upload brz-fs-lg-28 brz-fss-lg-px brz-fw-lg-500 brz-ls-lg-0 brz-lh-lg-1_4 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-mt-lg-30 brz-css-hH62A\" data-uniq-id=\"hzq6c\" data-generated-css=\"brz-css-yZWib\"><span class=\"brz-cp-color8 brz-underline-true\">OFT AN ODYSSEY UNTIL THE DIAGNOSIS IS REACHED<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-8qel4i brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-3mtwij\" data-brz-custom-id=\"t9DPmu1px8t0\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-lr9tv\" data-uniq-id=\"evhYN\" data-generated-css=\"brz-css-uEjFq\"><span class=\"brz-cp-color8\">Noonan syndrome is a rare genetic disorder that affects approximately 40 newborns per year in Switzerland. In the past, the diagnosis of Noonan syndrome was made solely based on clinical features (characteristic facial appearance, congenital heart defects, short stature). Today, genetic testing is also performed, although in about 20% of cases no genetic mutation can be identified. People with mild forms often remain undiagnosed throughout their lives.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-170tcq8 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1phwqex\" data-brz-custom-id=\"k1X66VFQlMzF\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-v5DTl\" data-generated-css=\"brz-css-yv0xL\" data-uniq-id=\"c2IZg\"><span class=\"brz-cp-color8\">Die Hauptschwierigkeit beim Noonan-Syndrom ist das breite Spektrum der Symptome. Aus diesem Grund kann es oft l\u00e4ngere Zeit dauern, bis die Diagnose gestellt wird. Nicht immer sind die \u00c4rzte auf der Entbindungsstation oder der zust\u00e4ndige Kinderarzt mit den vielen Spielarten des Noonan Syndroms vertraut. Wenn der Verdacht klar ist, wird das Kind an einen Genetiker \u00fcberwiesen. Die Eltern brauchen dann einen Arzt, der sich mit dem Syndrom auskennt und der die Vielfalt der Symptome erkl\u00e4ren und ein Vertrauensverh\u00e4ltnis aufbauen kann. Der betreffende Arzt sollte auch in der Lage sein, die spezifischen Probleme, die durch das Noonan-Syndrom verursacht werden, vorauszusehen und die verschiedenen Spezialisten zum richtigen Zeitpunkt hinzuzuziehen, um deren Hilfe in Anspruch zu nehmen. Es kann schwierig sein, einen Fachmann zu finden, der diese Rolle \u00fcbernehmen kann, und in den meisten F\u00e4llen m\u00fcssen Eltern die Rolle des Koordinators des &#8222;Care-Teams&#8220; \u00fcbernehmen.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-samwj\" data-generated-css=\"brz-css-pviBl\" data-uniq-id=\"b3p4Y\"><span class=\"brz-cp-color8\"> <\/span><\/p>\n<p class=\"brz-tp-lg-empty brz-ff-hUOhIoGTmLLs brz-ft-upload brz-fs-lg-17 brz-fss-lg-px brz-fw-lg-500 brz-ls-lg-0 brz-lh-lg-1_3 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-xL14r translation-block\" data-generated-css=\"brz-css-bNlaY\" data-uniq-id=\"wwbD8\">At PEZZ, parents of children with Noonan syndrome are supported by a leading expert in this field, Prof. Dr. Dr. med. Kees Noordam.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-columns brz-css-d-column-column brz-css-uey23\" data-brz-custom-id=\"uwlJppZFcSlE\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-vrh7lk\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-mpfslx brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-zu7z2s\" data-brz-custom-id=\"vtk38g0x5lOz\">\n<div data-brz-translate-text=\"1\">\n<h4 data-generated-css=\"brz-css-qlxQk\" data-uniq-id=\"doCUh\" class=\"brz-tp-lg-heading4 brz-css-btajd\"><span class=\"brz-cp-color8\">MAIN CHARACTERISTICS<\/span><\/h4>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1mw5w35 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1f8vsaz\" data-brz-custom-id=\"xGZDKnxIk8Ox\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-nJeeo\" data-generated-css=\"brz-css-oVUxL\" data-uniq-id=\"puD7u\"><span class=\"brz-cp-color8\">FACE<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1g0un6s brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-7tgm4a\" data-brz-custom-id=\"yCFykAaEkyom\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-bq0RD\" data-generated-css=\"brz-css-eEUq8\" data-uniq-id=\"gJM11\"><span class=\"brz-cp-color8\">Typical facial features can often already be observed in newborns. The degree of these features varies widely and they tend to be less pronounced in adulthood. Common findings include a triangular face shape, widely spaced eyes, drooping eyelids, a small lower jaw, low-set ears, a short neck, and a low posterior hairline forming a W-shape.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1ycjn5k brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-g0c6xe\" data-brz-custom-id=\"zMQfNZETKINZ\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-my5xq\" data-uniq-id=\"tMI6c\" data-generated-css=\"brz-css-fuRWZ\"><span class=\"brz-cp-color8\">HEART<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-inovzh brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1tbwrki\" data-brz-custom-id=\"tqExxBpkli3P\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-oaz0m\" data-uniq-id=\"mVNnu\" data-generated-css=\"brz-css-uBdGn\"><span class=\"brz-cp-color8\">Congenital heart defects are a second important clue in making the diagnosis. A narrowing of the pulmonary valve is particularly common. This leads to increased strain on the heart, and the child has reduced physical endurance and tires more easily. The occurrence of additional heart defects is possible. A heart murmur is often audible in the first days after birth, or the child feeds poorly and appears pale.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-4ra5i7 brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-1ntc03w\" data-brz-duration=\"300\" data-brz-custom-id=\"pp8Mk2tkQpPS\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-x030b6 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1vvf0g7\" data-brz-custom-id=\"nLh0uCXd3ySW\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-q6YEU\" data-uniq-id=\"k3f9L\" data-generated-css=\"brz-css-bj5nB\"><span class=\"brz-cp-color8\">SMALL SIZE<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-d9m8nq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-538w4j\" data-brz-custom-id=\"k8mZK5fMyQlJ\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-gtYRp\" data-uniq-id=\"zoEn_\" data-generated-css=\"brz-css-kBdmY\"><span class=\"brz-cp-color8\">Obwohl das Geburtsgewicht und die Geburtsgr\u00f6sse in der Regel normal sind, sind Kinder mit Noonan-Syndrom sp\u00e4ter kleiner als f\u00fcr ihr Alter erwartet. Die Pubert\u00e4t verz\u00f6gert sich um etwa 2 Jahre und die Endgr\u00f6sse wird erst sp\u00e4t erreicht. M\u00e4nnern erreichen zwischen 157 und 169 cm, Frauen zwischen 148 und 153 cm.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1lmoo4a brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1tj1dlw\" data-brz-custom-id=\"rF_7BXJoXh4e\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-meEL7\" data-uniq-id=\"othKr\" data-generated-css=\"brz-css-g01bl\"><span class=\"brz-cp-color8\">MUSCULOSKELETAL SYSTEM<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-mg26ic brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-o02jnj\" data-brz-custom-id=\"ecBMGyOrj3Ee\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-mQtPC\" data-generated-css=\"brz-css-psK12\" data-uniq-id=\"pboNy\"><span class=\"brz-cp-color8\">On physical examination, reduced muscle tone is noticeable. Chest wall deformities (pectus excavatum, pectus carinatum, scoliosis) may also be present, as well as a tendency to develop lymphoedema. In boys, undescended testes are common.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1hgk574 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1p2sxsm\" data-brz-custom-id=\"vmGovsPkBk1j\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-pC5xo\" data-uniq-id=\"mElkG\" data-generated-css=\"brz-css-b2mHU\"><span class=\"brz-cp-color8\">BLEEDING DISORDERS<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-110tib brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-7k3q7k\" data-brz-custom-id=\"aWKAEZrVbzvB\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-uOUtX\" data-generated-css=\"brz-css-otkIa\" data-uniq-id=\"msyNU\"><span class=\"brz-cp-color8\">Disorders related to blood clotting also occur more frequently. They may present as easy bruising, heavy menstrual bleeding, or increased blood loss after surgery. Therefore, blood clotting should always be assessed before an operation, and the anaesthetist should be informed.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-y4cl3r brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1rjz2h8\" data-brz-custom-id=\"nChsZOXP8qw4\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-x4tNT\" data-uniq-id=\"ajuAF\" data-generated-css=\"brz-css-h3cjb\"><span class=\"brz-cp-color8\">EYES<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-mnyigo brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1k0q4n0\" data-brz-custom-id=\"lBzSRIyouSgz\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-cJg0o\" data-uniq-id=\"f0Uo2\" data-generated-css=\"brz-css-n16bN\"><span class=\"brz-cp-color8\">About 90% of affected individuals have a refractive error and require glasses, and the risk of strabismus is increased.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-99g1jh brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-sqtsge\" data-brz-custom-id=\"nAQQDIpMAzXD\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-hZhjm\" data-uniq-id=\"fW8uC\" data-generated-css=\"brz-css-tIKQh\"><span class=\"brz-cp-color8\">CHRONIC PAIN<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1yvbhhq brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-lvsxq\" data-brz-custom-id=\"pfZVXlroNHzX\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-ijghv\" data-generated-css=\"brz-css-eXcmm\" data-uniq-id=\"pjVpi\"><span class=\"brz-cp-color8\">Since the entire organ system may be subtly affected, many children and adults with Noonan syndrome experience pain in the joints, extremities, back, muscles, or abdomen.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-gsmubl brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1rzeb65\" data-brz-custom-id=\"sT89lYeOgHyg\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-sYGfD\" data-uniq-id=\"ewo1o\" data-generated-css=\"brz-css-eT3Kh\"><span class=\"brz-cp-color8\">FEEDING PROBLEMS IN THE FIRST TWO YEARS<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1paw9jg brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-hrhrk\" data-brz-custom-id=\"z6BWZnnZWzIs\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-jPXCE\" data-uniq-id=\"sOMxf\" data-generated-css=\"brz-css-zL9Pz\"><span class=\"brz-cp-color8\">Parents often remember the difficulties with feeding and drinking most vividly. The most common problems include poor sucking, refusal to drink, recurrent and sometimes forceful vomiting, bloating, and constipation. In the first year, children gain weight only very slowly. From the second year onwards, the situation usually improves. However, most children continue to have a poor appetite and remain thin.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1bsucww brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1wacmm7\" data-brz-custom-id=\"lvTU6swuk2e6\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-qBUfJ\" data-uniq-id=\"yX3ve\" data-generated-css=\"brz-css-ddNkY\"><span class=\"brz-cp-color8\">PSYCHOMOTOR DEVELOPMENT AND BEHAVIOUR<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-vqllan brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-tn8fap\" data-brz-custom-id=\"u1QTA0MbD92w\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-nWvhU\" data-generated-css=\"brz-css-fsumb\" data-uniq-id=\"lSQRc\"><span class=\"brz-cp-color8\">Due to muscle hypotonia, motor milestones such as crawling, standing, and walking are reached later. In some cases, there is also a delay in speech development. Cognitive abilities are within the normal range in up to 80% of cases, with an IQ between 70 and 120. Learning difficulties are present in about one third of cases. There are reports of deficits in the ability to recognise and respond appropriately to emotions (alexithymia). Many parents also observe attention difficulties, mood disturbances, and low frustration tolerance in their children.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-9e55nk brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1qiny5b\" data-brz-custom-id=\"fYk6Y2yi0YxZ\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-yBVZF\" data-uniq-id=\"o7Azj\" data-generated-css=\"brz-css-lJzYQ\"><span class=\"brz-cp-color8\">GUIDELINES FOR TREATMENT<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1vj4cl4 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1ynshxb\" data-brz-custom-id=\"xtPbulBC61N2\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-jPatz\" data-generated-css=\"brz-css-fux0Q\" data-uniq-id=\"kbrS9\"><span class=\"brz-cp-color8\">Jedes Kind ist anders &#8211; jedes Kind braucht andere Formen der Hilfe und unterschiedliche individuelle Unterst\u00fctzung. Die Hilfe von Experten &#8211; Spezialisten verschiedener Fachrichtungen, Kardiologen, Kinder\u00e4rzten, Logop\u00e4den, Physiotherapeuten, Psychologen \u2013 ist daher sehr wichtig. Ebenso hilfreich sind die Ratschl\u00e4ge und Erfahrungen anderer Eltern von Kindern mit Noonan-Syndrom, die z. B. \u00fcber Elternselbsthilfegruppen ausgetauscht werden k\u00f6nnen.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-gfe5k3 brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-1ocf49h\" data-brz-duration=\"300\" data-brz-custom-id=\"vLgxTBVqroAA\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-11wfmgv brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1ksguga\" data-brz-custom-id=\"u1PzTdvbGPLu\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-dKgAs\" data-uniq-id=\"fea3i\" data-generated-css=\"brz-css-rPyIJ\"><span class=\"brz-cp-color8\">After confirming the diagnosis through genetic testing, the following examinations should be carried out.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-u8iiut brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1ay7zi8\" data-brz-custom-id=\"up8IiV8y8kUq\">\n<div data-brz-translate-text=\"1\">\n<ul>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-zNNPu\" data-uniq-id=\"bSjrJ\" data-generated-css=\"brz-css-mJisp\"><span class=\"brz-cp-color8\">A comprehensive cardiac examination (including an ultrasound of the heart),<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-be1y4\" data-uniq-id=\"nEd3t\" data-generated-css=\"brz-css-bU3bx\"><span class=\"brz-cp-color8\">Eine Ultraschalluntersuchung der Nieren,<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-cL0Pe\" data-uniq-id=\"t4AS4\" data-generated-css=\"brz-css-amfEc\"><span class=\"brz-cp-color8\">Assessment of testicular descent,<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-bGMbx\" data-uniq-id=\"svKGm\" data-generated-css=\"brz-css-maWYr\"><span class=\"brz-cp-color8\">Eye examinations<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-rGCKC\" data-uniq-id=\"engbi\" data-generated-css=\"brz-css-pgQeh\"><span class=\"brz-cp-color8\">Assessment of hearing<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-ao85A\" data-uniq-id=\"qE5iV\" data-generated-css=\"brz-css-iT2Kv\"><span class=\"brz-cp-color8\">Bei h\u00e4ufigem Erbrechen sollten Untersuchungen zum Nachweis eines gastro-\u00f6sophagealen Refluxes und einer Malrotation durchgef\u00fchrt und entsprechend behandelt werden. In schweren F\u00e4llen kann eine Sondenern\u00e4hrung notwendig sein.<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-r3r5_\" data-uniq-id=\"f8EHI\" data-generated-css=\"brz-css-nT5C_\"><span class=\"brz-cp-color8\">Eine Entwicklungsbeurteilung sollte am Ende des ersten Lebensjahres und bei Eintritt in die Grundschule und in die weiterf\u00fchrenden Schulen erfolgen.<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-eXuwr\" data-uniq-id=\"hg4mo\" data-generated-css=\"brz-css-iuPh1\"><span class=\"brz-cp-color8\">Bei Bedarf braucht es eine psychosoziale Betreuung f\u00fcr Kind und Eltern.<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-vhcc7\" data-uniq-id=\"dGJQC\" data-generated-css=\"brz-css-h_bpx\"><span class=\"brz-cp-color8\">Eine Basisuntersuchung der Blutgerinnung sollte nach dem 5. Lebensjahr durchgef\u00fchrt werden oder fr\u00fcher, wenn eine gr\u00f6ssere Operation geplant ist.<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-nFX55\" data-uniq-id=\"gPKXb\" data-generated-css=\"brz-css-l_TFs\"><span class=\"brz-cp-color8\">Die Schilddr\u00fcsenfunktion sollte alle 3-5 Jahre kontrolliert werden.<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-cfqCO\" data-uniq-id=\"aRj2O\" data-generated-css=\"brz-css-x3c0o\"><span class=\"brz-cp-color8\">Entwicklungsverz\u00f6gerungen, die durch die muskul\u00e4re Hypotonie verursacht werden, verbessern sich mit Besch\u00e4ftigungs- und Physiotherapie.<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-sfpF8\" data-uniq-id=\"dg8zT\" data-generated-css=\"brz-css-nJcrf\"><span class=\"brz-cp-color8\">Wachstums- und Gewichtsentwicklung sollte anhand der Noonan-spezifischen Wachstumskurven erfolgen. Wenn nach dem Alter von 2 Jahren die K\u00f6rpergr\u00f6sse unter dem Mittelwert f\u00fcr Noonan-Syndrom-Standard liegt, muss eine Beurteilung durch einen p\u00e4diatrischen Endokrinologen erfolgen. In der Schweiz wird die Wachstumshormontherapie aktuell nur bei nachgewiesenem Wachstumshormonmangel bezahlt. Daher sollten bei Kleinwuchs und IGF-1-Spiegel &lt; -1 SD Wachstumshormonstimulationsteste durchgef\u00fchrt werden.<\/span><\/li>\n<li class=\"brz-tp-lg-uSRJcAJTJCVu brz-bcp-color8 brz-css-rjBH6\" data-uniq-id=\"fqhFn\" data-generated-css=\"brz-css-cqRH5\"><span class=\"brz-cp-color8\">Es ist sinnvoll, im Erwachsenenalter erneut neuropsychologische Tests durchzuf\u00fchren, wenn der Patient Symptome einer Stimmungs-\/Angstst\u00f6rung aufweist.<\/span><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"kallmann\" data-brz-id=\"fxE0FX5PYuP0_fxE0FX5PYuP0\" class=\"brz-section brz-css-d-section brz-css-1ouqsfz\">\n<div class=\"brz-section__content brz-section--fullWidth brz-css-d-sectionitem-bg brz-css-1ojm47g\" data-brz-custom-id=\"rNKyPPtUCsCo\">\n<div class=\"brz-container brz-css-d-sectionitem-container brz-css-1ykdhd4\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1q42vjy brz-wrapper\">\n<div class=\"brz-image brz-css-d-image-h8yqebf8kco_-parent brz-css-b0a9ro\" data-brz-custom-id=\"h8YQeBf8kCO_\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/12\/pezz-kallmann.webp\" loading=\"lazy\" title=\"Eine Hand auf dem Treppengel\u00e4nder\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"kallmann-info\" data-brz-id=\"ry6k8jaR6cFy_ry6k8jaR6cFy\" class=\"brz-section brz-css-d-section brz-css-8usm0\">\n<div class=\"brz-section__content brz-section--boxed brz-css-d-sectionitem-bg brz-css-1lhj76e\" data-brz-custom-id=\"lcmOzXd2YHWG\">\n<div class=\"brz-bg\">\n<div class=\"brz-bg-color\"><\/div>\n<\/div>\n<div class=\"brz-container brz-css-d-sectionitem-container brz-css-1xi53es\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-wd52cy brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-yuxqw\" data-brz-custom-id=\"wVxvR3S8blEU\">\n<div data-brz-translate-text=\"1\">\n<h2 class=\"brz-text-xs-left brz-ff-qKYqBgi9lfgW brz-ft-upload brz-fs-lg-70 brz-fss-lg-px brz-fw-lg-400 brz-ls-lg-0 brz-lh-lg-1 brz-vfw-lg-600 brz-fwdth-lg-100 brz-fsft-lg-0 brz-mb-lg-0 brz-mb-sm-0 brz-mb-xs-0 brz-tp-lg-heading2 brz-text-lg-left brz-css-c6tb5\" data-generated-css=\"brz-css-bSECZ\" data-uniq-id=\"yol2F\"><span class=\"brz-cp-color8\">KALLMANN SYNDROM<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-row__container brz-css-d-row-row brz-css-g96wv6\" data-brz-custom-id=\"stvw4laEkn91\">\n<div class=\"brz-row brz-css-d-row-container brz-css-8yygyi\">\n<div class=\"brz-columns brz-css-d-column-column brz-css-1t4ybx6\" data-brz-custom-id=\"dgazMXnrSlhT\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-3wp593\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-75a95e brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1tr1gwf\" data-brz-custom-id=\"m6MjTo3yuK7c\">\n<div data-brz-translate-text=\"1\">\n<h3 class=\"brz-mt-lg-0 brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_4 brz-ls-lg-0 brz-fw-lg-500 brz-fss-lg-px brz-fs-lg-28 brz-ft-upload brz-ff-hUOhIoGTmLLs brz-tp-sm-heading3 brz-tp-lg-heading3 brz-css-mpblq\" data-generated-css=\"brz-css-sXPps\" data-uniq-id=\"iY9G3\"><span class=\"brz-underline-true brz-cp-color8\">IN ALLER REGEL OHNE BEHANDLUNG KEINE PUBERT\u00c4TSENTWICKLUNG<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-kd8f5p brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-th7hvc\" data-brz-custom-id=\"wYpBulrGDACP\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-zEYyr\" data-generated-css=\"brz-css-pP9lb\" data-uniq-id=\"mMUwU\"><span class=\"brz-cp-color8\">Das Kallmann Syndrom ist definiert als gleichzeitiges Bestehen einer St\u00f6rung des Geruchssinns und einer fehlenden Steuerung der Hoden durch das Zwischenhirn.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-columns brz-css-d-column-column brz-css-1ymzyu9\" data-brz-custom-id=\"xVckRp58WiYn\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-z7lbl7\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-z7jwrp brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-9qcrms\" data-brz-custom-id=\"dOvC2toDpZvk\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-aTY_2\" data-generated-css=\"brz-css-v679D\" data-uniq-id=\"fbdSa\"><span class=\"brz-cp-color8\">GERUCHSINN<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-s5hmmc brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-3tnrjr\" data-brz-custom-id=\"lUxkzgBLkKvu\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_3 brz-ls-lg-0 brz-fw-lg-500 brz-fss-lg-px brz-fs-lg-17 brz-ft-upload brz-ff-hUOhIoGTmLLs brz-tp-lg-empty brz-css-s9rLK\" data-uniq-id=\"lMkaT\" data-generated-css=\"brz-css-kyBQ6\"><span class=\"brz-cp-color8\">Die Zellen f\u00fcr den Geruchssinn wie auch die Zellen, welche die Signale f\u00fcr die Steuerung der Hoden weitervermitteln entstehen aus Vorl\u00e4uferzellen, die in ihrer Entwicklung von gemeinsamen Steuersignalen abh\u00e4ngen. Beim Kallmann-Syndrom kommt es infolge mehrerer bekannter Gendefekte zu einer gest\u00f6rten Entwicklung dieser Vorl\u00e4uferzellen. Dies f\u00fchrt dazu, dass Betroffene Ger\u00fcche nicht wahrnehmen k\u00f6nnen und in aller Regel ohne Behandlung keine Pubert\u00e4tsentwicklung erleben.<\/span><\/p>\n<p class=\"brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_3 brz-ls-lg-0 brz-fw-lg-500 brz-fss-lg-px brz-fs-lg-17 brz-ft-upload brz-ff-hUOhIoGTmLLs brz-tp-lg-empty brz-css-kj6Sp\" data-uniq-id=\"d2YKP\" data-generated-css=\"brz-css-rjXR7\"><\/p>\n<p class=\"brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-400 brz-lh-lg-1_3 brz-ls-lg-0 brz-fw-lg-500 brz-fss-lg-px brz-fs-lg-17 brz-ft-upload brz-ff-hUOhIoGTmLLs brz-tp-lg-empty brz-css-sHS09\" data-uniq-id=\"q0h5S\" data-generated-css=\"brz-css-hlBit\"><span class=\"brz-cp-color8\">Die H\u00e4ufigkeit liegt bei etwa 1:10\u2019000 f\u00fcr M\u00e4nner. Auch Frauen k\u00f6nnen betroffen sein (1:50&#8217;000), wobei die Diagnose bei Nichteinsetzen der Menstruation, jedoch normalen \u00e4usseren Geschlechtsorganen oft erst sp\u00e4t gestellt wird.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-11qe6ld brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-6cezcr\" data-brz-duration=\"300\" data-brz-custom-id=\"yDL_869HLqW8\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-17qg5z7 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1xatt0l\" data-brz-custom-id=\"dttwJFcDLpSx\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-mjz_c\" data-generated-css=\"brz-css-mZ14p\" data-uniq-id=\"jGLCT\"><span class=\"brz-cp-color8\">Die Betroffenen nehmen in der Regel nicht wahr, dass ihr Geruchssinn nicht wie bei den anderen funktioniert, weil sie ja damit aufwachsen und nichts anderes kennen. Meistens wird erst die ausbleibende Pubert\u00e4tsentwicklung bemerkt, wobei es manchmal erstaunlich lange geht, bis die Diagnose gestellt und die Betroffenen ad\u00e4quat medizinisch versorgt werden k\u00f6nnen. Die Ursache f\u00fcr die verz\u00f6gerte Diagnose liegt darin, dass Betroffene und oft auch behandelnde \u00c4rzte davon ausgehen, dass es sich um einen sogenannten &#8222;Sp\u00e4tentwickler&#8220; im Sinne einer Normvariante handle. Weitere Auff\u00e4lligkeiten sind ein Hochwuchs (im Verh\u00e4ltnis zur Elterngr\u00f6sse) mit langen Extremit\u00e4ten; \u00fcberdurchschnittlich h\u00e4ufig treten zudem H\u00f6rst\u00f6rungen und Nierenfehlbildungen auf.<\/span><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-bX9H0\" data-generated-css=\"brz-css-yb3Xs\" data-uniq-id=\"e2UvV\"><\/p>\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-qnJV3\" data-generated-css=\"brz-css-mIBUB\" data-uniq-id=\"xm3hZ\"><span class=\"brz-cp-color8\">Die betroffenen Jugendlichen und auch die erwachsenen M\u00e4nner brauchen eine lebenslange Ersatzbehandlung mit m\u00e4nnlichem Geschlechtshormon. Mit einer ad\u00e4quaten Behandlung sind die Pubert\u00e4tsentwicklung und auch das sp\u00e4tere Sexualleben normal. Solange allerdings nur das m\u00e4nnliche Geschlechtshormon ersetzt wird, kommt es zu keiner Reifung der Samenzellen. Sobald eine Fruchtbarkeit gew\u00fcnscht wird, braucht es eine andere, etwas komplizierter Behandlung mit \u00fcbergeordneten Steuerhormonen. <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"klinefelter\" data-brz-id=\"dls3Cb6SIweE_dls3Cb6SIweE\" class=\"brz-section brz-css-d-section brz-css-kgi7qm\">\n<div class=\"brz-section__content brz-section--fullWidth brz-css-d-sectionitem-bg brz-css-54djkd\" data-brz-custom-id=\"itJx4dPwSpQ0\">\n<div class=\"brz-container brz-css-d-sectionitem-container brz-css-1tj7aut\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-14lmaz8 brz-wrapper\">\n<div class=\"brz-image brz-css-d-image-fqsoqknuou_t-parent brz-css-1ohnq92\" data-brz-custom-id=\"fQSoQknuou_T\"><img decoding=\"async\" class=\"brz-img\" src=\"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/12\/pezz-klinefelter.webp\" loading=\"lazy\" title=\"Dei Paar F\u00fcsse die im Kreis auf einer Wiese stehen\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"klinefelter-info\" data-brz-id=\"aoWoiF25ndrR_aoWoiF25ndrR\" class=\"brz-section brz-css-d-section brz-css-p1nzv1\">\n<div class=\"brz-section__content brz-section--boxed brz-css-d-sectionitem-bg brz-css-1h8ithp\" data-brz-custom-id=\"q3OgBtkbbh03\">\n<div class=\"brz-bg\">\n<div class=\"brz-bg-color\"><\/div>\n<\/div>\n<div class=\"brz-container brz-css-d-sectionitem-container brz-css-1sc9hrb\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1nu7375 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-1gppcn0\" data-brz-custom-id=\"toNRPokYL2e0\">\n<div data-brz-translate-text=\"1\">\n<h2 class=\"brz-text-lg-left brz-tp-lg-heading2 brz-mb-xs-0 brz-mb-sm-0 brz-mb-lg-0 brz-fsft-lg-0 brz-fwdth-lg-100 brz-vfw-lg-600 brz-lh-lg-1 brz-ls-lg-0 brz-fw-lg-400 brz-fss-lg-px brz-fs-lg-70 brz-ft-upload brz-ff-qKYqBgi9lfgW brz-text-xs-left brz-css-hN1xR\" data-uniq-id=\"eJcU_\" data-generated-css=\"brz-css-mDpd2\"><span class=\"brz-cp-color8\">KLINEFELTER SYNDROM<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-row__container brz-css-d-row-row brz-css-g3wmhy\" data-brz-custom-id=\"mQ0q5KSon6if\">\n<div class=\"brz-row brz-css-d-row-container brz-css-k3c3z8\">\n<div class=\"brz-columns brz-css-d-column-column brz-css-11vufxv\" data-brz-custom-id=\"hNmpxIeSgHsW\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-1f6vsnz\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-cgxti0 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-q413ui\" data-brz-custom-id=\"r8muc5UHYXYa\">\n<div data-brz-translate-text=\"1\">\n<h3 class=\"brz-tp-lg-heading3 brz-tp-sm-heading3 brz-ff-hUOhIoGTmLLs brz-ft-upload brz-fs-lg-28 brz-fss-lg-px brz-fw-lg-500 brz-ls-lg-0 brz-lh-lg-1_4 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-mt-lg-0 brz-css-btNRZ\" data-uniq-id=\"dJjJD\" data-generated-css=\"brz-css-s7K8A\"><span class=\"brz-cp-color8 brz-underline-true\">DIE H\u00c4UFIGSTE CHROMOSOMENST\u00d6RUNG BEIM MANN<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-9u6vp0 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-19bkjvg\" data-brz-custom-id=\"zi4FkRP4lXUm\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-x2AlP\" data-uniq-id=\"cl4ny\" data-generated-css=\"brz-css-g_dWk\"><span class=\"brz-cp-color8\">Das Klinefelter Syndrom ist die h\u00e4ufigste Chromosomenst\u00f6rung beim Mann. Etwa jedes tausendste m\u00e4nnliche Neugeborene ist davon betroffen. Oft wird die Diagnose erst im Erwachsenenalter gestellt &#8211; wenn ein Paar ungewollt kinderlos bleibt. Knaben und M\u00e4nner mit Klinefelter-Syndrom haben in ihrem Chromosomensatz ein X zu viel: anstelle von 46 Chromosomen mit einem X- und einem Y-Chromosom besteht der Chromosomensatz aus 47 Chromosomen mit einem Y Chromosom und 2 X-Chromosomen.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"brz-columns brz-css-d-column-column brz-css-1cggr2z\" data-brz-custom-id=\"dk_IXe169zLM\">\n<div class=\"brz-column__items brz-css-d-column-bg brz-css-i4lfh8\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-7idp6o brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-ggpldr\" data-brz-custom-id=\"jmoz0EmGhOE2\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-paragraph brz-css-sChDC\" data-generated-css=\"brz-css-w6rBQ\" data-uniq-id=\"ohjdo\"><span class=\"brz-cp-color8\">KNABEN MIT KLINEFELTER-SYNDROM SIND OFT GR\u00d6SSER ALS MAN AUF GRUND DES FAMILIENRAHMENS ERWARTEN W\u00dcRDE.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-qpa462 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-zwujzj\" data-brz-custom-id=\"ys9sPURmNCZJ\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-empty brz-ff-hUOhIoGTmLLs brz-ft-upload brz-fs-lg-17 brz-fss-lg-px brz-fw-lg-500 brz-ls-lg-0 brz-lh-lg-1_3 brz-vfw-lg-400 brz-fwdth-lg-100 brz-fsft-lg-0 brz-css-ghA0b\" data-generated-css=\"brz-css-kwqSE\" data-uniq-id=\"lVlzz\"><span class=\"brz-cp-color8\">Als spezielle Besonderheit ist oft die Beinl\u00e4nge mehr betroffen als die L\u00e4nge des Oberk\u00f6rpers. Einzelne Knaben mit Klinefelter-Syndrom haben eine fehlende oder unvollst\u00e4ndige Pubert\u00e4t, die meisten zeigen aber mit Ausnahme des Hodenwachstums eine normale Entwicklung: M\u00e4nner mit Klinefelter-Syndrom haben in der Regel ein Hodenvolumen, welches deutlich zu klein und in der Regel nicht gr\u00f6sser als 5 ml ist. Da die spermienbildenden Zellen st\u00e4rker betroffen sind als die Zellen, die das m\u00e4nnliche Geschlechtshormon Testosteron produzieren, bleibt die Hormonversorgung oft \u00fcber l\u00e4ngere Zeit ausreichend. Eine verminderte Spermienkonzentration im Samenerguss kann jedoch zu Unfruchtbarkeit f\u00fchren. In den Hoden selbst sind allerdings oft Spermien vorhanden. Es konnte in den letzten Jahren gezeigt werden, dass solche Spermien mit technischen Mitteln gewonnen werden und mit einer Eizelle verschmolzen, der Partnerin in die Geb\u00e4rmutter eingesetzt  zu einer normalen Schwangerschaft f\u00fchren k\u00f6nnen.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-70r6be brz-wrapper\">\n<div class=\"brz-accordion brz-css-d-accordion brz-css-n8wa89\" data-brz-duration=\"300\" data-brz-custom-id=\"zuM_jxxgaCOC\">\n<div class=\"brz-accordion__item\">\n<div class=\"brz-accordion__nav\" data-brz-collapsible=\"off\">\n<p data-brz-translate-text=\"1\" class=\"brz-accordion__nav-title brz-p brz-text__editor\">MORE<\/p>\n<\/div>\n<div class=\"brz-accordion__content brz-d-xs-flex brz-flex-xs-column\">\n<div class=\"brz-accordion__item-content brz-d-xs-flex brz-flex-xs-column\">\n<div id=\"\" class=\"brz-css-d-wrapper brz-css-1fcg646 brz-wrapper\">\n<div class=\"brz-rich-text brz-rich-text__custom brz-css-d-richtext brz-css-sgfhr3\" data-brz-custom-id=\"bOLa7EQ1ruX5\">\n<div data-brz-translate-text=\"1\">\n<p class=\"brz-tp-lg-uSRJcAJTJCVu brz-css-c5ufM\" data-uniq-id=\"z9_7i\" data-generated-css=\"brz-css-ut4e1\"><span class=\"brz-cp-color8\">Bei ausreichender eigener Produktion des m\u00e4nnlichen Geschlechtshormons oder, falls n\u00f6tig, dank einer Ersatzbehandlung mit m\u00e4nnlichem Geschlechtshormon sind M\u00e4nner mit Klinefelter-Syndrom normal sexuell aktiv. Es ist allerdings bekannt, dass vor allem Jugendliche mit Klinefelter-Syndrom w\u00e4hrend Pubert\u00e4t und Adoleszenz h\u00e4ufiger psychologische Probleme zeigen als Jugendliche mit normalem Chromosomensatz. Dies bedarf manchmal einer besonderen Betreuung von erfahrenen Jugend\u00e4rzten und Psychologen.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section><\/div>\n<p><!-- version:1774346409 --><\/p>","protected":false},"excerpt":{"rendered":"<p>SYNDROME SYNDROME MIT HORMONST\u00d6RUNGEN Es gibt hunderte von verschiedenen Syndromen. Wir beschr\u00e4nken uns hier auf h\u00e4ufige Syndrome, die mit Hormonst\u00f6rungen einhergehen. MENU TAB Turner Syndrom SGA-Mangelgeburt Prader-Willi Syndrom Noonan Syndrom Kallmann Syndrom Klinefelter Syndrom TURNER SYNDROM BEI M\u00c4DCHEN BUCH TAB F\u00fcr weitere Informationen verweisen wir auch auf die Brosch\u00fcre Das Turner-Syndrom und seine Gesichter, die <a href=\"https:\/\/www.pezz.ch\/en\/fuer-familien\/syndrome\/\" class=\"more-link\">&#8230;<span class=\"screen-reader-text\">  Syndromes<\/span><\/a><\/p>","protected":false},"author":5,"featured_media":0,"parent":813,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"brizy-blank-template.php","meta":{"iawp_total_views":488,"footnotes":""},"class_list":["post-4754","page","type-page","status-publish","hentry"],"brizy_media":[{"id":706,"url":"https:\/\/www.pezz.ch\/wp-content\/uploads\/2024\/07\/Ups-Fehler404.svg?t=1778422406","name":"Ups-Fehler404.svg","meta":{"brizy_attachment_uid":"wp-765135df340545b2c5be12821b17dc0c.svg","brizy_post_uid":["c22bc5dd32e8f25aa92e735451f512d0"]}},{"id":1699,"url":"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/06\/punkt-rot.webp","name":"punkt-rot.webp","meta":{"brizy_attachment_uid":"wp-59ff7eeef95958e2014af8db136d85ae.webp","brizy_post_uid":["c22bc5dd32e8f25aa92e735451f512d0"]}},{"id":1879,"url":"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/06\/zu-klein-zu-gross-buecher-pezz.webp","name":"zu-klein-zu-gross-buecher-pezz.webp","meta":{"brizy_attachment_uid":"wp-db6dd7c354b0d8606a00f46eac662a6b.webp","brizy_post_uid":["c22bc5dd32e8f25aa92e735451f512d0"]}},{"id":2275,"url":"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/07\/2025-pezz-4team-eiholzer-lindadagliorti-319.webp","name":"2025-pezz-4team-eiholzer-lindadagliorti-319.webp","meta":{"brizy_attachment_uid":"wp-14825792e74534556f5090db9c0a5ff8.webp","brizy_post_uid":["c22bc5dd32e8f25aa92e735451f512d0"]}},{"id":2276,"url":"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/07\/2025-pezz-4team-noordam-lindadagliorti-372.webp","name":"2025-pezz-4team-noordam-lindadagliorti-372.webp","meta":{"brizy_attachment_uid":"wp-52f337ad39e834857b41f1e93fd4687e.webp","brizy_post_uid":["c22bc5dd32e8f25aa92e735451f512d0"]}},{"id":2685,"url":"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/07\/pezz-kinderhormonzentrum.webp","name":"pezz-kinderhormonzentrum.webp","meta":{"brizy_attachment_uid":"wp-b9ba32e1ed4cabe138a0d2adb92929af.webp","brizy_post_uid":["4a7a5e3bfddd835bce8f05d6ceffddf2","c22bc5dd32e8f25aa92e735451f512d0"]}},{"id":2738,"url":"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/07\/pezz-wachstumsfragen.webp","name":"pezz-wachstumsfragen.webp","meta":{"brizy_attachment_uid":"wp-be6c16ecfa0e46002ab87be045f6072b.webp","brizy_post_uid":["4a7a5e3bfddd835bce8f05d6ceffddf2","c22bc5dd32e8f25aa92e735451f512d0"]}},{"id":2742,"url":"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/07\/pezz-pubertaet.webp","name":"pezz-pubertaet.webp","meta":{"brizy_attachment_uid":"wp-3f9cfad1cbe331cf58030ec136a643c9.webp","brizy_post_uid":["4a7a5e3bfddd835bce8f05d6ceffddf2","c22bc5dd32e8f25aa92e735451f512d0"]}},{"id":2803,"url":"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/07\/pezz-secondopinion.webp","name":"pezz-secondopinion.webp","meta":{"brizy_attachment_uid":"wp-201517bc81636b4ad935ccfefe91c3b9.webp","brizy_post_uid":["4a7a5e3bfddd835bce8f05d6ceffddf2","c22bc5dd32e8f25aa92e735451f512d0"]}},{"id":2853,"url":"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/07\/pezz-hormonstoerungen.webp","name":"pezz-hormonstoerungen.webp","meta":{"brizy_attachment_uid":"wp-1bbc734265dbf73bb9554afa5586cbef.webp","brizy_post_uid":["4a7a5e3bfddd835bce8f05d6ceffddf2","c22bc5dd32e8f25aa92e735451f512d0"]}},{"id":2854,"url":"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/07\/pezz-syndrome.webp","name":"pezz-syndrome.webp","meta":{"brizy_attachment_uid":"wp-5254c3e7e8554c087b9e8c15367b59bf.webp","brizy_post_uid":["4a7a5e3bfddd835bce8f05d6ceffddf2","c22bc5dd32e8f25aa92e735451f512d0"]}},{"id":2980,"url":"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/07\/pezz-topbild-familien.webp","name":"pezz-topbild-familien.webp","meta":{"brizy_attachment_uid":"wp-a24ab95bd73d02d255ab94f3f1036367.webp","brizy_post_uid":["c22bc5dd32e8f25aa92e735451f512d0"]}},{"id":3121,"url":"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/07\/pezz-topbild-daspezz.webp","name":"pezz-topbild-daspezz.webp","meta":{"brizy_attachment_uid":"wp-5f54cee1349255372d0e11da7726eeb4.webp","brizy_post_uid":["4a7a5e3bfddd835bce8f05d6ceffddf2","c22bc5dd32e8f25aa92e735451f512d0"]}},{"id":3124,"url":"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/08\/pezz-topbild-instrumente.webp","name":"pezz-topbild-instrumente.webp","meta":{"brizy_attachment_uid":"wp-1de391ad3c54402856a8dd05f5a5b7d8.webp","brizy_post_uid":["4a7a5e3bfddd835bce8f05d6ceffddf2","c22bc5dd32e8f25aa92e735451f512d0"]}},{"id":3164,"url":"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/08\/pezz-medien-01.webp","name":"pezz-medien-01.webp","meta":{"brizy_attachment_uid":"wp-5cf99cc38660dc3120aa5c860e0a90eb.webp","brizy_post_uid":["4a7a5e3bfddd835bce8f05d6ceffddf2","c22bc5dd32e8f25aa92e735451f512d0"]}},{"id":3165,"url":"https:\/\/www.pezz.ch\/wp-content\/uploads\/2025\/08\/pezz-paket-01.webp","name":"pezz-paket-01.webp","meta":{"brizy_attachment_uid":"wp-a928191810c06cf48c5ef59463f7900d.webp","brizy_post_uid":["4a7a5e3bfddd835bce8f05d6ceffddf2","c22bc5dd32e8f25aa92e735451f512d0"]}},{"id":3169,"url":"https:\/\/www.pezz.ch\/wp-content\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